AMLOTAN-27.5

# Amlodipine 2.5 mg + Losartan Potassium 25 mg ## SHORT DESCRIPTION Amlodipine 2.5 mg + Losartan Potassium 25 mg is a **combination antihypertensive medicine** used to help lower high blood pressure (hypertension). It combines a calcium channel blocker, amlodipine, with an angiotensin II receptor blocker (ARB), losartan. By working through two complementary mechanisms, the combination helps relax blood vessels, reduce resistance to blood flow, and lower blood pressure. Controlling hypertension can help reduce the long-term risk of complications such as heart attack, stroke, and kidney problems. ## KEY BENEFITS * Helps lower high blood pressure * Combines two medicines with complementary blood-pressure-lowering effects * Amlodipine relaxes and widens blood vessels * Losartan blocks the effects of angiotensin II, helping blood vessels remain relaxed * May provide effective blood-pressure control when a single medicine is insufficient * Helps reduce the long-term risk of cardiovascular complications associated with uncontrolled hypertension * Convenient combination therapy in a single tablet ## USES / INDICATIONS Amlodipine 2.5 mg + Losartan Potassium 25 mg may be prescribed for: * **Hypertension (high blood pressure)** * Blood pressure that is not adequately controlled with a single antihypertensive medicine * Patients who require combination therapy with an ARB and calcium channel blocker * Other cardiovascular indications when specifically determined by a healthcare professional This medicine is **not intended for emergency treatment of a sudden severe increase in blood pressure**. ## HOW IT WORKS ### Amlodipine Amlodipine is a **calcium channel blocker (CCB)**. It reduces the movement of calcium into the smooth muscle cells of blood vessels. This causes the arteries to relax and widen, reducing resistance to blood flow and lowering blood pressure. ### Losartan Potassium Losartan is an **angiotensin II receptor blocker (ARB)**. It blocks the action of angiotensin II, a hormone that normally causes blood vessels to constrict and promotes sodium and water retention. By blocking angiotensin II, losartan: * Relaxes blood vessels * Reduces blood pressure * Decreases aldosterone-related sodium and water retention * Reduces pressure within the cardiovascular system ## DOSAGE & ADMINISTRATION * Take Amlodipine 2.5 mg + Losartan 25 mg exactly as prescribed by your doctor. * It is commonly taken **once daily**. * Take it at approximately the same time each day. * The tablet may generally be taken with or without food. * Swallow the tablet with water. * Your doctor may adjust the dose depending on your blood pressure, response to treatment, kidney function, and other medicines. * Continue taking the medicine even if you feel well, unless your doctor tells you to stop. * Do not change the dose or discontinue treatment without medical advice. ### Missed Dose If you miss a dose, take it when you remember unless it is nearly time for the next dose. Do not take two doses together to compensate for a missed dose. ## SIDE EFFECTS ### Common Side Effects * Dizziness * Headache * Swelling of the ankles or feet * Flushing * Fatigue * Palpitations * Low blood pressure * Nausea * Mild stomach discomfort Amlodipine commonly causes peripheral edema, while losartan may cause dizziness, particularly when treatment is started or the dose is increased. ### Serious Side Effects Seek immediate medical attention if you experience: * Severe dizziness or fainting * Severe allergic reaction * Swelling of the face, lips, tongue, or throat * Difficulty breathing * Significant reduction in urine output * Severe weakness * Irregular heartbeat * Signs of dangerously high potassium levels, such as marked weakness, palpitations, or abnormal heartbeat ## PRECAUTIONS & WARNINGS Tell your doctor before taking this medicine if you have: * Kidney disease * Liver disease * Heart failure * Low blood pressure * High potassium levels * Dehydration * A history of angioedema * Significant heart valve disease * Any condition requiring potassium monitoring ### Important Safety Information * Losartan can increase **potassium levels** in the blood. * Kidney function and potassium levels may need to be monitored during treatment. * Avoid potassium supplements or potassium-containing salt substitutes unless recommended by your doctor. * Excessive dehydration, vomiting, diarrhea, or heavy sweating may increase the risk of low blood pressure or kidney problems. * Amlodipine may cause ankle or leg swelling. * Rise slowly from sitting or lying positions if you experience dizziness. * Do not stop antihypertensive treatment without medical advice. * **Losartan should not be used during pregnancy.** If pregnancy occurs, contact your doctor promptly. * Tell your doctor if you are breastfeeding or planning pregnancy. ## DRUG INTERACTIONS Amlodipine + Losartan may interact with: * **Potassium supplements and potassium-containing salt substitutes** — may increase blood potassium levels. * **Potassium-sparing diuretics** such as spironolactone — may increase the risk of hyperkalemia. * **NSAIDs** such as ibuprofen and naproxen — may reduce the blood-pressure-lowering effect and increase the risk of kidney problems in susceptible patients. * **Other blood-pressure medicines** — may increase the risk of excessive blood-pressure reduction. * **Lithium** — losartan may increase lithium concentrations and toxicity risk. * **Certain medicines affecting CYP3A4** — may alter amlodipine concentrations. * **Other medicines affecting kidney function** — may increase the risk of renal impairment. * **Alcohol** — may increase dizziness or low blood pressure. Always tell your doctor or pharmacist about all prescription medicines, over-the-counter medicines, vitamins, and herbal supplements you take. ## STORAGE INFORMATION * Store Amlodipine 2.5 mg + Losartan 25 mg according to the manufacturer's instructions. * Keep the tablets in their original packaging. * Store at room temperature unless otherwise specified on the product label. * Protect from excessive heat and moisture. * Keep away from direct sunlight when applicable. * Keep out of the sight and reach of children. * Do not use after the expiry date. * Do not use tablets if the packaging is damaged or the tablets appear abnormal. ## PRESCRIPTION STATUS **Prescription Medicine** Amlodipine 2.5 mg + Losartan Potassium 25 mg should be used under the supervision of a qualified healthcare professional. Prescription requirements may vary depending on the country and formulation. ## GENUINE MEDICINE ASSURANCE When purchasing Amlodipine 2.5 mg + Losartan Potassium 25 mg: * Purchase from a licensed and reputable pharmacy. * Check that the packaging is sealed and intact. * Verify the medicine name, ingredients, and strength. * Check the batch number and expiry date. * Ensure the product has been stored appropriately. * Avoid products with damaged, altered, or suspicious packaging. * Consult a pharmacist if you have concerns about authenticity or product quality. ## FAQ — FREQUENTLY ASKED QUESTIONS ### What is Amlodipine 2.5 mg + Losartan 25 mg used for? It is used to lower high blood pressure. The combination contains amlodipine, a calcium channel blocker, and losartan, an angiotensin II receptor blocker. ### How does Amlodipine lower blood pressure? Amlodipine relaxes and widens blood vessels by reducing calcium entry into vascular smooth muscle cells. This lowers resistance to blood flow and reduces blood pressure. ### How does Losartan 25 mg lower blood pressure? Losartan blocks angiotensin II receptors. This prevents angiotensin II from constricting blood vessels and promoting sodium and water retention, helping lower blood pressure. ### Can Amlodipine and Losartan be taken together? Yes. These medicines are commonly combined because they lower blood pressure through different mechanisms. The appropriate combination and dose should be determined by a healthcare professional. ### Should Amlodipine + Losartan be taken with food? The combination can generally be taken with or without food. Take it consistently at approximately the same time each day. ### Can Amlodipine + Losartan cause dizziness? Yes. Dizziness can occur, particularly when starting treatment or after a dose increase. Rise slowly from sitting or lying down and avoid driving if you feel dizzy. ### Does Amlodipine cause swollen ankles? Yes. **Ankle or leg swelling (peripheral edema)** is a relatively common side effect of amlodipine. Inform your doctor if swelling is persistent, severe, or worsening. ### Can Losartan increase potassium levels? Yes. Losartan can increase potassium levels, particularly in people with kidney disease or those taking potassium supplements or potassium-sparing medicines. ### Can I take potassium supplements with Losartan? Do not take potassium supplements or potassium-containing salt substitutes unless your doctor specifically recommends them. Losartan can increase blood potassium levels. ### Can I take Ibuprofen with Amlodipine + Losartan? Regular use of NSAIDs such as ibuprofen may reduce the blood-pressure-lowering effect and increase the risk of kidney problems, particularly in people who are dehydrated or have existing kidney disease. Consult your doctor before regular use. ### Can Amlodipine + Losartan be used during pregnancy? Losartan should not be used during pregnancy because medicines that act on the renin-angiotensin system can harm the developing fetus. Contact your doctor immediately if you become pregnant while taking this medicine. ### Can I stop Amlodipine + Losartan when my blood pressure becomes normal? Do not stop treatment without medical advice. A normal blood-pressure reading may indicate that the medicine is working effectively rather than that treatment is no longer necessary. ### How long does Amlodipine + Losartan take to work? Blood pressure may begin to decrease after treatment starts, but the full blood-pressure-lowering effect can take longer to develop. Your doctor may monitor your blood pressure and adjust the dose if necessary. ### What should I do if I miss a dose? Take the missed dose when you remember unless it is nearly time for your next dose. Do not take two doses together. ### Can Amlodipine + Losartan be taken with other blood pressure medicines? It may be combined with other antihypertensive medicines in selected patients, but doing so can increase the risk of low blood pressure or other adverse effects. Use combinations only under medical supervision. ### Is Amlodipine + Losartan a diuretic? No. Amlodipine is a calcium channel blocker and losartan is an angiotensin II receptor blocker. Neither medicine is classified as a diuretic. ### Is Amlodipine + Losartan available without a prescription? It is generally a prescription medicine and should be used under the supervision of a qualified healthcare professional. ## MEDICAL DISCLAIMER This information is provided for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Amlodipine 2.5 mg + Losartan Potassium 25 mg should be used only as prescribed by a qualified healthcare professional. The appropriate dose depends on blood pressure, kidney and liver function, other medicines, medical history, and individual response. Do not start, stop, or change the dose without medical advice. **Losartan should not be used during pregnancy.** Seek urgent medical attention for severe allergic reactions, fainting, severe dizziness, difficulty breathing, or symptoms of significant electrolyte or kidney problems.