ASOMEX-LT

# LOSARTAN POTASSIUM 50 MG + S-AMLODIPINE 2.5 MG ## SHORT DESCRIPTION **Losartan Potassium 50 mg + S-Amlodipine 2.5 mg** is a prescription combination medicine used primarily for the management of **high blood pressure (hypertension)**. It combines an angiotensin II receptor blocker (ARB) with a calcium channel blocker (CCB) to provide complementary blood-pressure-lowering effects. Losartan helps relax blood vessels by blocking the action of angiotensin II, while **S-Amlodipine (levamlodipine)** relaxes blood vessels by reducing calcium entry into vascular smooth muscle. --- ## KEY BENEFITS * Helps reduce **high blood pressure**. * Combines two antihypertensive medicines with complementary mechanisms. * Helps relax and widen blood vessels. * May provide better blood-pressure control when one medicine alone is insufficient. * Helps reduce the long-term cardiovascular risks associated with uncontrolled hypertension. * Once-daily combination therapy may simplify treatment for appropriate patients. * S-Amlodipine may provide effective blood-pressure reduction at a relatively low dose. --- ## USES / INDICATIONS ### Hypertension Losartan Potassium + S-Amlodipine may be prescribed for: * Treatment of **essential hypertension**. * Patients whose blood pressure is not adequately controlled with a single antihypertensive medicine. * Patients who require combination therapy to achieve their individual blood-pressure target. ### Cardiovascular Risk Reduction Effective long-term blood-pressure control can help reduce the risk of complications associated with hypertension, including: * Stroke * Heart attack * Heart failure * Kidney damage > This medicine controls blood pressure but does not permanently cure hypertension. Long-term treatment may be required. --- ## HOW IT WORKS ### Losartan Potassium 50 mg Losartan is an **angiotensin II receptor blocker (ARB)**. Angiotensin II normally causes blood vessels to constrict and promotes sodium and water retention. Losartan blocks the **AT1 receptor**, reducing these effects. **Losartan → blocks angiotensin II → relaxes blood vessels → lowers blood pressure.** ### S-Amlodipine 2.5 mg S-Amlodipine, also known as **levamlodipine**, is the active S-enantiomer of amlodipine and belongs to the **dihydropyridine calcium channel blocker** class. It reduces calcium entry into vascular smooth muscle cells, causing the blood vessels to relax and widen. **S-Amlodipine → relaxes vascular smooth muscle → widens blood vessels → lowers blood pressure.** ### Combined Effect The two medicines lower blood pressure through different pathways, providing complementary antihypertensive effects. --- ## DOSAGE & ADMINISTRATION * Take Losartan Potassium 50 mg + S-Amlodipine 2.5 mg **exactly as prescribed**. * It is generally administered **once daily**, depending on the specific product and physician's instructions. * It can generally be taken **with or without food**. * Take it at approximately the same time each day. * Swallow the tablet whole with water unless the product instructions state otherwise. ### Dose Adjustment Your healthcare professional may adjust the dose based on: * Blood-pressure response * Age * Kidney function * Liver function * Other medicines * Tolerability Do not change the dose without medical advice. ### Missed Dose Take the missed dose when remembered unless it is close to the next scheduled dose. **Do not take two doses together.** ### Monitoring Regular monitoring of: * Blood pressure * Kidney function * Serum potassium may be recommended during treatment. --- ## SIDE EFFECTS ### Common Side Effects Possible side effects include: * Dizziness * Headache * Fatigue * Flushing * Swelling of the ankles or feet * Palpitations * Mild gastrointestinal discomfort ### Losartan-Related Effects Losartan may cause: * Dizziness * Low blood pressure * Increased potassium levels * Changes in kidney function ### S-Amlodipine-Related Effects S-Amlodipine may cause: * Ankle swelling (edema) * Headache * Flushing * Dizziness * Palpitations * Fatigue ### Serious Side Effects Seek urgent medical attention for: * Severe dizziness or fainting * Facial, lip, tongue, or throat swelling * Difficulty breathing * Severe allergic reaction * Significant reduction in urine output * Symptoms suggesting dangerously high potassium, such as unusual weakness or abnormal heart rhythm --- ## PRECAUTIONS & WARNINGS ### Pregnancy **Losartan should not be used during pregnancy**, particularly after pregnancy is recognized, because medicines that act on the renin-angiotensin system can cause serious fetal harm. If you become pregnant while taking this medicine, contact your healthcare professional promptly. ### Kidney Function Losartan can affect kidney function, particularly in patients with: * Kidney disease * Dehydration * Renal artery stenosis * Heart failure Kidney function may need monitoring. ### High Potassium Losartan can increase blood potassium levels. Tell your doctor if you have kidney disease or use potassium supplements or potassium-containing salt substitutes. ### Low Blood Pressure Dizziness or fainting can occur, particularly: * At the beginning of treatment * After dose increases * During dehydration * When taking other blood-pressure-lowering medicines ### Liver Disease Tell your healthcare professional if you have liver disease because dose adjustments may be necessary. ### Aortic or Mitral Valve Stenosis Amlodipine should be used cautiously in patients with certain severe heart-valve disorders. ### Heart Failure Patients with severe heart disease should use the combination under appropriate medical supervision. ### Elderly Patients Older adults may be more susceptible to dizziness and low blood pressure. --- ## DRUG INTERACTIONS ### Potassium Supplements Losartan may increase potassium levels. Combining it with potassium supplements should only be done under medical supervision. ### Potassium-Sparing Diuretics Medicines such as: * Spironolactone * Eplerenone * Amiloride may increase the risk of **hyperkalemia** when combined with losartan. ### NSAIDs Regular use of NSAIDs such as: * Ibuprofen * Naproxen * Diclofenac may reduce the blood-pressure-lowering effect and increase the risk of kidney problems, particularly in patients who are dehydrated or have kidney disease. ### Lithium Losartan may increase lithium concentrations and the risk of lithium toxicity. ### Other Antihypertensives Combining this medicine with other blood-pressure-lowering medicines can increase the risk of **hypotension**. ### CYP3A4 Inhibitors S-Amlodipine/amlodipine is metabolized primarily through CYP3A4. Strong CYP3A4 inhibitors may increase amlodipine exposure. ### Grapefruit Grapefruit or grapefruit juice may increase exposure to amlodipine in some individuals. Discuss regular grapefruit consumption with your healthcare professional. ### Aliskiren Combining an ARB such as losartan with aliskiren is generally avoided in patients with **diabetes or significant kidney impairment** because of increased risks of hypotension, hyperkalemia, and kidney impairment. Always inform your doctor or pharmacist about **all prescription medicines, OTC medicines, vitamins, and herbal supplements** you use. --- ## STORAGE INFORMATION * Store according to the **manufacturer's instructions**. * Keep the tablets in the original packaging. * Store in a cool, dry place. * Protect from excessive heat, moisture, and direct sunlight. * Keep the container tightly closed. * Keep out of reach of children. * Do not use after the expiry date. * Do not use tablets if the packaging is damaged. --- ## PRESCRIPTION STATUS **Losartan Potassium 50 mg + S-Amlodipine 2.5 mg is generally a prescription medicine.** Because this combination can affect blood pressure, kidney function, and potassium levels, it should be used under the supervision of a qualified healthcare professional. --- ## GENUINE MEDICINE ASSURANCE When purchasing Losartan Potassium 50 mg + S-Amlodipine 2.5 mg, ensure that: * The medicine comes in **original, sealed manufacturer packaging**. * The label clearly states both active ingredients and their strengths. * The manufacturer's name and information are present. * The **batch/lot number and expiry date** are clearly visible. * The packaging shows no signs of tampering. * The product is purchased from a **licensed pharmacy or authorized medicine supplier**. * The product has appropriate regulatory authorization. * The formulation and strength match the prescription. Do not use medicine that is expired, damaged, improperly stored, or suspected to be counterfeit. --- # FAQ – LOSARTAN POTASSIUM 50 MG + S-AMLODIPINE 2.5 MG ### 1. What is Losartan Potassium 50 mg + S-Amlodipine 2.5 mg used for? It is primarily used to treat **high blood pressure (hypertension)** when combination treatment is appropriate. ### 2. What is Losartan? Losartan is an **angiotensin II receptor blocker (ARB)** that relaxes blood vessels and lowers blood pressure. ### 3. What is S-Amlodipine? S-Amlodipine, or **levamlodipine**, is the S-enantiomer of amlodipine and is a calcium channel blocker that relaxes blood vessels. ### 4. Why are Losartan and S-Amlodipine combined? They lower blood pressure through **different mechanisms**, which can provide additional blood-pressure control compared with either medicine alone in appropriate patients. ### 5. Can Losartan + S-Amlodipine cure hypertension? No. It controls blood pressure but does not permanently cure the underlying tendency toward hypertension. Long-term treatment may be required. ### 6. How often should this medicine be taken? It is commonly prescribed **once daily**, but follow the exact instructions provided by your healthcare professional. ### 7. Can I take this medicine with food? Yes. It can generally be taken **with or without food**. ### 8. Can Losartan + S-Amlodipine cause dizziness? Yes. Dizziness can occur, especially when starting treatment or after a dose increase. Rise slowly from sitting or lying down. ### 9. Can this medicine cause swollen ankles? Yes. **Ankle or leg swelling (peripheral edema)** is a recognized effect of amlodipine-type medicines. ### 10. Can Losartan increase potassium? Yes. Losartan can increase blood potassium levels, particularly in people with kidney disease or those taking potassium supplements or potassium-sparing medicines. ### 11. Can I take potassium supplements with Losartan? Do not take potassium supplements or potassium-containing salt substitutes without discussing them with your healthcare professional. ### 12. Can I take ibuprofen with Losartan? Regular NSAID use, including ibuprofen, can potentially reduce the antihypertensive effect and increase kidney-related risks. Discuss regular NSAID use with your doctor or pharmacist. ### 13. Can I stop this medicine if my blood pressure becomes normal? Do not stop it without medical advice. A normal blood-pressure reading may indicate that the medicine is working effectively. ### 14. What should I do if I miss a dose? Take it when remembered unless it is close to the next dose. **Do not double the dose.** ### 15. Can I take Losartan + S-Amlodipine during pregnancy? Losartan can cause serious fetal harm and **should not be used during pregnancy**. Contact your healthcare professional immediately if pregnancy occurs while taking this medicine. ### 16. Can I drink alcohol while taking this medicine? Alcohol may increase dizziness and low blood pressure. Limit or avoid alcohol until you know how the medicine affects you. ### 17. Can I take this medicine with other blood-pressure medicines? Sometimes combination therapy is prescribed, but using multiple antihypertensive medicines can increase the risk of low blood pressure. Use them only under medical supervision. ### 18. How long does Losartan + S-Amlodipine take to work? Blood pressure may begin to decrease after treatment starts, but the full effect can take **days to several weeks**, depending on the individual and dose. ### 19. What monitoring may be needed? Your healthcare professional may monitor **blood pressure, kidney function, and potassium levels**, particularly after starting treatment or changing the dose. ### 20. Is Losartan Potassium 50 mg + S-Amlodipine 2.5 mg available without a prescription? It is generally **prescription-only** because treatment requires appropriate dose selection and monitoring. --- ## MEDICAL DISCLAIMER This information about **Losartan Potassium 50 mg + S-Amlodipine 2.5 mg** is provided for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. The appropriate dose depends on the patient's **blood pressure, kidney and liver function, potassium level, age, other medicines, and overall medical condition**. **Do not start, stop, or change antihypertensive treatment without consulting a qualified healthcare professional. Losartan must not be used during pregnancy because medicines acting on the renin-angiotensin system can cause serious fetal harm.** Seek medical attention for severe dizziness, fainting, facial or throat swelling, difficulty breathing, or other serious symptoms.