BRUCET

# Ibuprofen 400 mg + Paracetamol 325 mg ## Short Description **Ibuprofen 400 mg + Paracetamol 325 mg** is a **combination pain-relieving and fever-reducing medicine** used to manage **mild to moderate pain, inflammation, and fever**. Ibuprofen is a **non-steroidal anti-inflammatory drug (NSAID)** that helps reduce pain and inflammation, while Paracetamol (Acetaminophen) works centrally to relieve pain and reduce fever. Together, they provide effective relief for a variety of painful conditions when used as directed. --- # Key Benefits Section - Provides effective relief from mild to moderate pain. - Helps reduce fever quickly and effectively. - Reduces inflammation and swelling. - Combines two complementary pain-relieving medicines for enhanced effectiveness. - Helps relieve muscle and joint pain. - Effective for headache, toothache, and back pain. - May improve comfort and daily functioning during painful conditions. - Convenient combination tablet for pain and fever management. --- # Uses / Indications Ibuprofen 400 mg + Paracetamol 325 mg is indicated for the relief of: ### Pain - Headache - Migraine - Toothache - Dental pain - Back pain - Neck pain - Muscle pain (Myalgia) - Joint pain - Sprains and strains - Sports injuries - Menstrual pain (Dysmenorrhea) - Post-operative pain (as prescribed) ### Fever - Fever associated with infections - Fever accompanying cold and flu ### Inflammatory Conditions - Mild inflammatory musculoskeletal conditions - Pain associated with arthritis (when advised by a healthcare professional) > **Note:** This medicine relieves symptoms but does not treat the underlying cause of infection or inflammation. --- # How It Works This combination contains two active ingredients with different mechanisms of action. ### Ibuprofen Ibuprofen is an **NSAID** that: - Inhibits cyclooxygenase (COX-1 and COX-2) enzymes. - Reduces the production of prostaglandins. - Decreases pain, inflammation, and fever. ### Paracetamol (Acetaminophen) Paracetamol: - Acts primarily within the central nervous system. - Reduces pain perception. - Lowers fever by acting on the body's temperature-regulating center in the brain. - Has minimal anti-inflammatory activity compared with ibuprofen. Together, these medicines provide broader pain relief than either ingredient alone in many patients. --- # Dosage & Administration Always take **Ibuprofen 400 mg + Paracetamol 325 mg** exactly as prescribed by your healthcare provider or according to the product label. ### General Guidelines - Swallow the tablet whole with water. - Preferably take after food or with milk to reduce stomach irritation from ibuprofen. - Maintain adequate hydration. - Use the lowest effective dose for the shortest duration necessary. - Do not exceed the recommended daily dose. - Do not combine with other products containing ibuprofen, paracetamol, or other NSAIDs unless advised by your healthcare provider. ### Missed Dose - If taking regularly, take the missed dose when remembered. - If it is nearly time for the next dose, skip the missed dose. - Do not take a double dose. --- # Side Effects Like all medicines, Ibuprofen + Paracetamol may cause side effects, although not everyone experiences them. ## Common Side Effects - Stomach discomfort - Indigestion - Heartburn - Nausea - Vomiting - Dizziness - Headache - Mild skin rash ## Less Common Side Effects - Constipation - Diarrhea - Fluid retention - Elevated blood pressure - Sleepiness ## Serious Side Effects (Seek Immediate Medical Attention) - Severe allergic reactions - Difficulty breathing - Swelling of the face, lips, tongue, or throat - Black or bloody stools - Vomiting blood - Severe stomach pain - Chest pain - Severe skin reactions - Yellowing of the skin or eyes (possible liver injury) - Reduced urine output or signs of kidney problems --- # Precautions & Warnings Before taking this medicine, inform your healthcare provider if you: - Have stomach ulcers or gastrointestinal bleeding. - Have kidney disease. - Have liver disease. - Have heart disease or high blood pressure. - Have asthma, especially if triggered by NSAIDs. - Have bleeding disorders. - Are pregnant or planning pregnancy. - Are breastfeeding. - Have a history of allergic reactions to NSAIDs or paracetamol. ### Important Warnings - Do not exceed the recommended dose. - Prolonged or excessive use of paracetamol may cause serious liver damage. - Ibuprofen may increase the risk of stomach ulcers, bleeding, heart attack, or stroke, especially with long-term use or higher doses. - Avoid alcohol, as it may increase the risk of stomach bleeding and liver damage. - Use caution in older adults, who may be at greater risk of side effects. - Seek medical attention if pain persists or worsens despite treatment. --- # Drug Interactions Ibuprofen + Paracetamol may interact with: ### Blood Thinners - Warfarin - Apixaban - Rivaroxaban ### Other Medicines - Aspirin - Other NSAIDs (e.g., naproxen, diclofenac) - Corticosteroids - ACE inhibitors - Angiotensin receptor blockers (ARBs) - Diuretics - Methotrexate - Lithium - Cyclosporine - Alcohol - Other medicines containing paracetamol Always inform your healthcare provider about all prescription medicines, over-the-counter medicines, vitamins, and herbal supplements you are taking. --- # Storage Information - Store below **30°C** in a cool, dry place. - Protect from moisture and direct sunlight. - Keep the tablets in the original packaging. - Keep out of reach of children. - Do not use after the expiry date. --- # Prescription Status **Prescription or Over-the-Counter (OTC) Medicine** Availability may vary depending on the country, strength, and local regulations. Use according to the product label or your healthcare provider's advice. --- # Genuine Medicine Assurance We provide **100% genuine, quality-assured medicines** sourced from authorized pharmaceutical manufacturers and licensed distributors. Every product is stored and handled according to recommended pharmaceutical standards to help maintain its quality, safety, and effectiveness. --- # Frequently Asked Questions (FAQ) ## 1. What is Ibuprofen 400 mg + Paracetamol 325 mg used for? It is used to relieve mild to moderate pain, reduce inflammation, and lower fever associated with conditions such as headache, toothache, muscle pain, back pain, menstrual cramps, and cold or flu. ## 2. How does this combination work? Ibuprofen reduces inflammation, pain, and fever by blocking prostaglandin production, while Paracetamol works mainly in the brain to relieve pain and reduce fever. ## 3. Can I take this medicine for fever? Yes. This combination is effective in reducing fever associated with infections or other illnesses. ## 4. Should I take this medicine with food? Yes. Taking it with food or milk may help reduce stomach irritation caused by ibuprofen. ## 5. Can I take additional Paracetamol with this medicine? Avoid taking additional paracetamol-containing medicines unless advised by your healthcare provider, as excessive doses may increase the risk of liver damage. ## 6. Can I take this medicine for headache? Yes. It is commonly used to relieve headaches and migraines, provided it is appropriate for your medical condition. ## 7. Is this medicine suitable for long-term use? It is generally intended for short-term use. Prolonged use should only occur under medical supervision due to the risks associated with NSAIDs and paracetamol. ## 8. Can I drink alcohol while taking this medicine? It is best to avoid alcohol, as it may increase the risk of stomach bleeding and liver damage. ## 9. Can this medicine cause stomach ulcers? Ibuprofen may increase the risk of stomach irritation, ulcers, and gastrointestinal bleeding, especially with prolonged use or in susceptible individuals. ## 10. Can pregnant women take this medicine? Consult your healthcare provider before use during pregnancy. Ibuprofen is generally avoided during the third trimester unless specifically recommended by a healthcare professional. ## 11. What should I do if I miss a dose? If taking regularly, take the missed dose when remembered unless it is nearly time for your next dose. Do not double the dose. ## 12. Can I take this medicine with antibiotics? In many cases, yes, but certain antibiotics and other medicines may interact. Consult your healthcare provider or pharmacist. ## 13. How should I store Ibuprofen + Paracetamol tablets? Store below 30°C in a cool, dry place, away from moisture, heat, and direct sunlight. ## 14. When should I seek immediate medical attention? Seek emergency medical care if you experience severe allergic reactions, difficulty breathing, black stools, vomiting blood, severe abdominal pain, yellowing of the skin or eyes, chest pain, or signs of kidney problems. --- # Medical Disclaimer The information provided on this page is intended for **educational and informational purposes only** and should not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. **Ibuprofen 400 mg + Paracetamol 325 mg** should be used only as directed. Seek immediate medical attention if you experience severe side effects, allergic reactions, signs of gastrointestinal bleeding, liver injury, or other serious symptoms. ```