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# Ibuprofen 400 mg + Paracetamol 352 mg ## Short Description **Ibuprofen 400 mg + Paracetamol 352 mg** is a combination pain-relief medicine containing an **NSAID (ibuprofen)** and an **analgesic/antipyretic (paracetamol)**. It is used for the short-term relief of **mild to moderate pain**, particularly when pain has an inflammatory component. Ibuprofen helps reduce pain and inflammation, while paracetamol provides additional pain-relieving and fever-reducing effects. The combination can provide greater pain relief than either ingredient alone for some acute pain conditions. > **Important:** The stated paracetamol strength is **352 mg per dosage unit**. Always check the product label because combination products can have different strengths and maximum daily doses. --- ## Key Benefits * Helps relieve **mild to moderate pain** * Provides pain relief through **two complementary mechanisms** * Ibuprofen helps reduce **inflammation and swelling** * Paracetamol helps relieve pain and **reduce fever** * May provide effective short-term relief for various acute painful conditions * Can be useful when pain involves both inflammation and general discomfort --- ## Uses / Indications Ibuprofen 400 mg + Paracetamol 352 mg may be used for short-term relief of: * **Headache** * **Toothache** * **Back pain** * **Muscle and joint pain** * **Sprains and strains** * **Period pain (menstrual cramps)** * **Musculoskeletal pain** * **Fever associated with pain** * Other mild to moderate acute pain conditions when appropriate The combination is intended for **symptomatic relief** and does not necessarily treat the underlying cause of pain. --- ## How It Works ### Ibuprofen 400 mg Ibuprofen is a **non-steroidal anti-inflammatory drug (NSAID)**. It inhibits cyclooxygenase (COX) enzymes, reducing the production of **prostaglandins**, which contribute to pain, inflammation, and fever. This helps reduce: * Pain * Inflammation * Swelling * Fever ### Paracetamol 352 mg Paracetamol acts primarily within the **central nervous system** to reduce pain perception and fever. It has relatively little anti-inflammatory activity compared with NSAIDs. ### Combination Effect Together, ibuprofen and paracetamol provide **complementary pain relief**, with ibuprofen addressing inflammatory pain and paracetamol providing additional analgesic and antipyretic effects. --- ## Dosage & Administration > **Important:** Follow the dosage instructions supplied with your specific product. The appropriate dose depends on age, medical history, other medicines, and the exact formulation. ### General Adult Use For adults, combination products containing ibuprofen 400 mg may commonly be taken as **one tablet per dose**, with the interval and maximum daily dose determined by the product labeling or healthcare professional. * Take with a full glass of water. * Taking the medicine **with or after food** may reduce stomach irritation. * Use the **lowest effective dose for the shortest necessary duration**. * Do not exceed the recommended daily dose. * Do not use for prolonged periods without medical advice. ### Important Paracetamol Precaution Because this medicine contains paracetamol, **do not take additional paracetamol-containing medicines** unless your doctor or pharmacist confirms that the combined daily amount is safe. Many cold, flu, headache, and pain medicines contain paracetamol. ### Missed Dose If taking the medicine regularly and you miss a dose, take it when remembered unless it is nearly time for the next dose. **Do not double the dose**. --- ## Side Effects ### Common Side Effects Possible side effects include: * Indigestion * Heartburn * Stomach discomfort * Nausea * Vomiting * Diarrhea * Constipation * Dizziness * Headache ### Serious Side Effects Stop taking the medicine and seek urgent medical attention if you experience: * **Black or bloody stools** * Vomiting blood or material resembling coffee grounds * Severe or persistent stomach pain * Difficulty breathing * Swelling of the face, lips, tongue, or throat * Severe skin rash, blistering, or peeling * Yellowing of the skin or eyes * Significant reduction in urine output * Chest pain * Sudden weakness or difficulty speaking Serious gastrointestinal bleeding, kidney injury, cardiovascular events, severe allergic reactions, and liver injury can occur, although these are uncommon. --- ## Precautions & Warnings Before taking Ibuprofen + Paracetamol, tell your healthcare professional if you have: * **Stomach ulcers or previous gastrointestinal bleeding** * Kidney disease * Liver disease * Heart disease * High blood pressure * Asthma triggered by aspirin or NSAIDs * Blood-clotting problems * Dehydration * A history of stroke or heart attack ### Stomach & Gastrointestinal Warning Ibuprofen can increase the risk of **stomach ulcers and gastrointestinal bleeding**. Risk may be higher in older adults and people taking anticoagulants, corticosteroids, antiplatelet medicines, or certain antidepressants. ### Kidney Warning NSAIDs can affect kidney function, particularly in people who are dehydrated or have existing kidney disease or heart failure. ### Liver Warning Excessive paracetamol can cause **serious liver damage**. Never exceed the recommended total daily paracetamol dose and avoid combining this medicine with other paracetamol-containing products without professional advice. ### Cardiovascular Warning NSAIDs may increase the risk of **heart attack or stroke**, particularly with higher doses or prolonged use. ### Pregnancy Ibuprofen should generally be **avoided during pregnancy unless specifically recommended by a healthcare professional**, and NSAIDs are particularly contraindicated during the later stages of pregnancy. If you are pregnant, planning pregnancy, or breastfeeding, consult your healthcare professional before taking this medicine. ### Alcohol Avoid or limit alcohol while taking this medicine. Alcohol can increase gastrointestinal irritation and bleeding risk and may increase the risk of liver injury from excessive paracetamol exposure. --- ## Drug Interactions Tell your doctor or pharmacist about all medicines you use. Potential interactions include: * **Other NSAIDs** such as aspirin, naproxen, diclofenac, or aceclofenac — increased risk of gastrointestinal and kidney-related adverse effects. * **Other paracetamol-containing medicines** — increased risk of paracetamol overdose and liver damage. * **Anticoagulants** such as warfarin — increased bleeding risk. * **Antiplatelet medicines** such as clopidogrel — increased bleeding risk. * **Corticosteroids** — increased risk of gastrointestinal ulcers and bleeding. * **SSRIs/SNRIs** — may increase gastrointestinal bleeding risk. * **ACE inhibitors/ARBs** — may increase kidney-related risks and affect blood-pressure control. * **Diuretics** — may increase kidney-related risks and reduce their effectiveness. * **Lithium** — ibuprofen may increase lithium concentrations. * **Methotrexate** — NSAIDs may increase methotrexate toxicity. * **Cyclosporine or tacrolimus** — may increase the risk of kidney toxicity. This list is not complete. Tell your healthcare professional about all prescription medicines, OTC medicines, vitamins, and supplements you take. --- ## Storage Information * Store at **room temperature** according to the product label. * Protect from excessive heat, moisture, and direct sunlight. * Keep the tablets in their original packaging. * Keep the container tightly closed. * Keep out of reach and sight of children. * Do not use after the expiry date. * Dispose of expired or unused medicine according to local recommendations. --- ## Prescription Status **Prescription status varies by country, formulation, and pack size.** Ibuprofen and paracetamol combination products may be available **without a prescription in some markets**, while certain strengths or formulations may require a prescription. Always follow local pharmacy regulations and the product-specific dosage instructions. --- ## Genuine Medicine Assurance When purchasing Ibuprofen 400 mg + Paracetamol 352 mg: * Purchase from a **licensed and reputable pharmacy** or authorized medicine supplier. * Check that the packaging is intact and properly sealed. * Verify the **medicine name, strength, batch number, manufacturing details, and expiry date**. * Confirm that the product contains the stated strengths of ibuprofen and paracetamol. * Do not use medicine from damaged, opened, or suspicious packaging. * Avoid medicines purchased from unauthorized sources. * If you suspect a product is counterfeit, consult a pharmacist or contact the manufacturer using the information printed on the original packaging. --- # FAQ – Ibuprofen 400 mg + Paracetamol 352 mg ### 1. What is Ibuprofen 400 mg + Paracetamol 352 mg used for? It is used for the **short-term relief of mild to moderate pain**, including headache, toothache, back pain, muscle pain, joint pain, menstrual pain, and some pain associated with inflammation. ### 2. Is Ibuprofen + Paracetamol a strong painkiller? It can provide effective relief for mild to moderate acute pain because it combines two medicines with different mechanisms of action. It is not an opioid painkiller. ### 3. What is the difference between Ibuprofen and Paracetamol? **Ibuprofen** is an NSAID that relieves pain and inflammation, while **paracetamol** primarily relieves pain and fever. Combining them can provide complementary pain relief. ### 4. Can Ibuprofen + Paracetamol be used for toothache? Yes. This combination may provide short-term relief from **dental pain**, but it does not treat the underlying dental problem. Persistent toothache should be assessed by a dentist. ### 5. Can Ibuprofen + Paracetamol be used for headache? It may be used for short-term relief of certain headaches. If headaches are frequent, severe, sudden, or accompanied by neurological symptoms, medical evaluation is recommended. ### 6. Can I take additional Paracetamol with this medicine? **Do not take additional paracetamol unless a healthcare professional confirms that the total daily amount is safe.** This product already contains paracetamol 352 mg per dosage unit. ### 7. Can I take Ibuprofen with this combination medicine? No, not routinely. The medicine already contains **ibuprofen 400 mg**, so taking additional ibuprofen could exceed the recommended NSAID dose and increase the risk of side effects. ### 8. Can I take Aspirin with Ibuprofen + Paracetamol? Do not combine aspirin with this medicine without medical advice. Both aspirin and ibuprofen are NSAIDs and can increase gastrointestinal bleeding and other adverse effects. ### 9. Should I take this medicine with food? Taking the medicine **with or after food** may help reduce stomach irritation. Always follow the instructions supplied with your specific product. ### 10. Can Ibuprofen + Paracetamol cause stomach ulcers? Yes. Because it contains ibuprofen, prolonged or high-dose use can increase the risk of **stomach ulcers and gastrointestinal bleeding**. ### 11. Can this medicine damage the liver? Excessive paracetamol intake can cause **serious liver damage**. The risk increases if you take multiple paracetamol-containing medicines or consume excessive alcohol. ### 12. Can this medicine affect the kidneys? Yes. Ibuprofen and other NSAIDs can affect kidney function, particularly in people with kidney disease, dehydration, heart failure, or those taking certain medicines. ### 13. Can I drink alcohol while taking Ibuprofen + Paracetamol? It is best to **avoid or limit alcohol**. Alcohol can increase stomach irritation and bleeding risk and may increase the risk of liver injury associated with excessive paracetamol intake. ### 14. Can pregnant women take Ibuprofen 400 mg + Paracetamol 352 mg? Consult a healthcare professional before use during pregnancy. **Ibuprofen should generally be avoided during pregnancy unless specifically recommended**, and NSAIDs should not be used during the later stages of pregnancy. ### 15. Can I take this medicine while breastfeeding? Ibuprofen and paracetamol are generally considered compatible with breastfeeding at usual doses, but combination products should still be used according to professional advice, particularly with repeated or prolonged use. ### 16. How long can I take Ibuprofen + Paracetamol? It is intended for **short-term use**. If pain persists or requires treatment for several days, consult a healthcare professional rather than continuing self-treatment indefinitely. ### 17. What happens if I take too much of this medicine? An overdose can cause serious complications, including **gastrointestinal bleeding, kidney injury, and potentially severe liver damage from paracetamol**. Seek urgent medical advice if you take more than recommended, even if you initially feel well. ### 18. Can children take Ibuprofen 400 mg + Paracetamol 352 mg? Do not give this specific-strength combination to children unless it has been **specifically prescribed or recommended for their age and weight**. Pediatric dosing differs from adult dosing. ### 19. Does Ibuprofen + Paracetamol make you sleepy? Sleepiness is not usually a major effect, but dizziness can occur. Avoid driving or operating machinery if you feel dizzy or impaired. ### 20. What should I do if I miss a dose? If you are taking it on a scheduled basis, take the missed dose when remembered unless it is nearly time for the next dose. **Do not take a double dose** to make up for a missed dose. --- ## Medical Disclaimer This information is provided for **educational and informational purposes only** and is not a substitute for professional medical advice, diagnosis, or treatment. Ibuprofen 400 mg + Paracetamol 352 mg should be used according to the specific product label and the instructions of a qualified healthcare professional. Because the product contains both an NSAID and paracetamol, taking additional NSAIDs or paracetamol-containing medicines may increase the risk of serious adverse effects. Use the **lowest effective dose for the shortest appropriate duration**. Seek urgent medical attention for severe allergic reactions, chest pain, vomiting blood, black stools, severe abdominal pain, significant reduction in urine, or suspected overdose.