DUPHASTON

# Dydrogesterone 10 mg ## SHORT DESCRIPTION Dydrogesterone 10 mg is a **synthetic progestogen** that is similar in action to the natural hormone progesterone. It is used for conditions associated with **progesterone deficiency**, including certain menstrual disorders, painful periods, endometriosis, irregular menstrual cycles and selected pregnancy-related indications under medical supervision. Dydrogesterone may also be used as part of **hormone replacement therapy (HRT)** with estrogen to help protect the uterine lining in women who have a uterus. ## KEY BENEFITS * Helps restore or support **progesterone activity** * Helps regulate irregular menstrual cycles * May reduce symptoms associated with painful periods * May be used in the management of **endometriosis** * Helps support the uterine lining during selected reproductive treatments * May be prescribed with estrogen during HRT to reduce estrogen-related overgrowth of the uterine lining * Generally has minimal androgenic and estrogenic activity compared with some older progestogens ## USES / INDICATIONS Dydrogesterone 10 mg may be prescribed for: * **Irregular menstrual periods** * Painful periods (dysmenorrhea) * Heavy or abnormal uterine bleeding associated with hormonal imbalance * **Endometriosis** * Premenstrual symptoms in selected patients * Secondary amenorrhea, when appropriate * Progesterone deficiency-related menstrual disorders * Luteal phase support in selected fertility treatments * Selected cases of threatened or recurrent miscarriage when specifically prescribed * Hormone replacement therapy alongside estrogen to protect the endometrium The indication and dosage vary depending on the condition being treated. ## HOW IT WORKS Dydrogesterone acts on **progesterone receptors** in the reproductive system. It helps produce progesterone-like effects on the endometrium, supporting normal transformation and stabilization of the uterine lining. Depending on the treatment schedule, it can help regulate menstrual bleeding and support the hormonal environment required for certain reproductive functions. ## DOSAGE & ADMINISTRATION The dosage of Dydrogesterone 10 mg depends significantly on the condition being treated. * Take exactly as prescribed by your doctor. * Tablets can generally be taken **with or without food**. * Try to take the medicine at the same time each day. * Swallow the tablet with water. * Do not change the dose or treatment schedule without medical advice. ### Examples of Commonly Used Regimens Treatment schedules may vary, but doctors may prescribe different regimens such as: * **Irregular or painful periods:** often 10 mg once or twice daily during specific days of the menstrual cycle. * **Endometriosis:** may require 10 mg one or more times daily for a specified period. * **HRT:** commonly prescribed for specific days of the cycle alongside estrogen. * **Fertility or pregnancy-related indications:** dosing and duration are individualized by the treating specialist. **These are examples only and are not a substitute for your prescribed regimen.** ### Missed Dose Take the missed dose when remembered. If it is close to the next scheduled dose, skip the missed dose and continue with the normal schedule. Do not take a double dose. ## SIDE EFFECTS Common side effects may include: * Headache * Migraine * Nausea * Abdominal discomfort * Breast tenderness * Menstrual spotting or irregular bleeding * Painful or heavier periods * Dizziness * Mood changes ### Serious Side Effects Contact a healthcare professional promptly if you experience: * Severe allergic reaction * Swelling of the face, lips or throat * Difficulty breathing * Significant unexplained vaginal bleeding * Symptoms suggesting liver problems, such as yellowing of the skin or eyes * Severe persistent abdominal pain * Severe headache or visual disturbances ## PRECAUTIONS & WARNINGS * Do not use dydrogesterone if you are allergic to dydrogesterone or any of its ingredients. * Tell your doctor if you have **unexplained vaginal bleeding** before starting treatment. * Inform your doctor about any current or previous **liver disease**. * Seek medical advice if jaundice or other symptoms of liver dysfunction occur. * Tell your doctor if you have a history of depression or significant mood disorders. * Dydrogesterone should not be used for every type of abnormal uterine bleeding; the underlying cause should be evaluated. * If prescribed during pregnancy, use it only under the supervision of your obstetrician or other qualified healthcare professional. * Tell your doctor if you are breastfeeding. * Report persistent or unusually heavy bleeding. * Regular medical follow-up may be required depending on the reason for treatment. ## DRUG INTERACTIONS Medicines that may affect dydrogesterone include drugs that alter liver enzyme activity, particularly **CYP3A4-inducing medicines**. Examples include: * **Rifampicin** * **Rifabutin** * **Carbamazepine** * **Phenytoin** * **Phenobarbital** * Certain antiretroviral or antiviral medicines * Some herbal products, particularly **St. John's wort** These medicines may increase the metabolism of dydrogesterone and potentially reduce its effectiveness. Always inform your doctor or pharmacist about all prescription medicines, over-the-counter medicines, vitamins and herbal supplements you take. ## STORAGE INFORMATION * Store according to the manufacturer's instructions. * Keep tablets in their original packaging. * Store at the recommended room temperature. * Protect from excessive heat, moisture and direct sunlight. * Keep out of reach of children. * Do not use after the expiry date. * Do not use tablets if the packaging is damaged. ## PRESCRIPTION STATUS **Prescription medicine.** Dydrogesterone 10 mg should be used under the supervision of a qualified healthcare professional. The appropriate dose and treatment duration depend on the medical condition and individual patient factors. ## GENUINE MEDICINE ASSURANCE For safe and genuine Dydrogesterone 10 mg: * Purchase from a licensed and reputable pharmacy. * Check the medicine name and strength. * Verify the manufacturer's details. * Check the batch number and expiry date. * Ensure the packaging and seal are intact. * Avoid products with damaged or suspicious packaging. * Do not purchase prescription medicines from unauthorized sources. * Consult a pharmacist if you have concerns about product authenticity. ## FAQ ### What is Dydrogesterone 10 mg used for? Dydrogesterone 10 mg is a progestogen used for conditions associated with **progesterone deficiency**, including irregular or painful periods, endometriosis and selected fertility or pregnancy-related indications. ### Is Dydrogesterone a progesterone medicine? Dydrogesterone is a **synthetic progestogen** that has progesterone-like effects. It is not identical to natural progesterone. ### How does Dydrogesterone work? It acts on progesterone receptors and helps regulate the uterine lining and menstrual cycle. ### Can Dydrogesterone regulate periods? Yes. It may be prescribed to help regulate menstrual cycles when hormonal imbalance or inadequate progesterone activity contributes to irregular bleeding. ### Can Dydrogesterone help with painful periods? Yes. Dydrogesterone may be prescribed as part of treatment for **dysmenorrhea (painful periods)** in selected patients. ### Is Dydrogesterone used for endometriosis? Yes. Dydrogesterone can be prescribed for **endometriosis** to produce progesterone-like effects and help manage associated symptoms. ### Is Dydrogesterone used during pregnancy? It may be prescribed in selected pregnancy-related situations, but treatment should only be taken under the supervision of an appropriate healthcare professional. ### Can Dydrogesterone help with fertility? Dydrogesterone may be used in selected fertility treatments to provide progesterone-like support, depending on the individual's reproductive treatment plan. ### Does Dydrogesterone help prevent miscarriage? It may be prescribed in selected cases of threatened or recurrent miscarriage when progesterone support is considered appropriate. However, it should only be used for this purpose under specialist medical supervision. ### Can Dydrogesterone be used for HRT? Yes. It can be combined with estrogen in **hormone replacement therapy** for women with an intact uterus to help protect the endometrium from excessive estrogen stimulation. ### Can Dydrogesterone delay periods? The effect on menstrual bleeding depends on the timing and reason for treatment. Dydrogesterone should not be used simply to delay periods without medical advice. ### What are the common side effects of Dydrogesterone? Common side effects include **headache, nausea, breast tenderness, menstrual spotting, irregular bleeding and abdominal discomfort**. ### Can Dydrogesterone cause bleeding or spotting? Yes. Spotting or changes in menstrual bleeding can occur, particularly during the first months of treatment or when treatment is started or stopped. ### Can Dydrogesterone cause weight gain? Weight changes are not considered the primary effect of dydrogesterone, although some individuals may notice changes in weight or fluid retention. Persistent or significant changes should be discussed with a doctor. ### Can Dydrogesterone cause sleepiness? Dizziness or tiredness may occur in some people. Avoid driving if you feel dizzy or impaired. ### Can Dydrogesterone be taken with food? Yes. Dydrogesterone can generally be taken **with or without food**. Taking it consistently in the same manner may help maintain a regular routine. ### What should I do if I miss a Dydrogesterone dose? Take it when remembered unless it is close to the next dose. Do not take two tablets together to compensate for a missed dose. ### Can Dydrogesterone be taken with birth control pills? This depends on the specific contraceptive and reason for taking dydrogesterone. Tell your doctor about all hormonal medicines you use before starting treatment. ### Can Dydrogesterone interact with other medicines? Yes. Medicines that increase liver enzyme activity, including some anticonvulsants and antibiotics such as rifampicin, may reduce dydrogesterone's effectiveness. ### Can I take Dydrogesterone while breastfeeding? Dydrogesterone should be used during breastfeeding only when recommended by a healthcare professional, who can assess the potential benefits and risks. ### How long can I take Dydrogesterone? The treatment duration depends on the condition being treated. Some regimens are limited to particular days of the menstrual cycle, while others may require longer treatment. ### Can I stop Dydrogesterone suddenly? Do not change or discontinue treatment without discussing it with your doctor, particularly if it has been prescribed for fertility treatment, pregnancy support or HRT. ### How should Dydrogesterone 10 mg be stored? Store according to the manufacturer's instructions, generally at room temperature away from excessive heat and moisture. Keep the tablets in their original packaging and out of reach of children. ## MEDICAL DISCLAIMER This information is provided for educational and informational purposes only and does not replace professional medical advice, diagnosis or treatment. **Dydrogesterone 10 mg is a prescription hormonal medicine and its dosage varies considerably depending on the condition being treated.** Unexplained vaginal bleeding should be medically evaluated before treatment. If used during pregnancy or fertility treatment, follow your specialist's instructions carefully. Seek medical attention for severe allergic reactions, jaundice, severe abdominal pain or unusually heavy bleeding. Always follow the specific product label and your healthcare professional's instructions.