HEFCARD 50

# Sacubitril 24 mg + Valsartan 26 mg ## Short Description **Sacubitril 24 mg + Valsartan 26 mg** is a **prescription combination medicine** belonging to the **Angiotensin Receptor-Neprilysin Inhibitor (ARNI)** class. It is primarily used to treat **chronic heart failure with reduced ejection fraction (HFrEF)**. Sacubitril enhances the body's natural protective heart hormones, while Valsartan blocks the harmful effects of angiotensin II, helping to improve heart function, reduce strain on the heart, lower the risk of hospitalization, and decrease cardiovascular mortality. > **Important:** This medicine should only be taken under the supervision of a qualified healthcare professional and is not intended for the immediate treatment of acute heart failure episodes. --- # Key Benefits Section - Helps manage chronic heart failure with reduced ejection fraction (HFrEF). - Reduces the risk of hospitalization due to heart failure. - Lowers the risk of cardiovascular death in eligible patients. - Improves the heart's ability to pump blood efficiently. - Helps reduce symptoms such as breathlessness and fatigue. - Promotes healthy blood vessel relaxation and lowers blood pressure. - Reduces excess fluid retention by enhancing natural natriuretic peptides. - Supports improved quality of life and exercise tolerance when used as part of a comprehensive heart failure treatment plan. --- # Uses / Indications Sacubitril 24 mg + Valsartan 26 mg is indicated for: ### Heart Failure - Chronic heart failure with reduced ejection fraction (HFrEF) - Reduction of cardiovascular death and heart failure-related hospitalization in appropriate patients ### Other Uses - May be prescribed for certain heart failure-related conditions as determined by a cardiologist. > **Note:** This medicine is not intended for the treatment of acute heart failure emergencies or hypertensive crises. --- # How It Works This medicine combines two active ingredients with complementary actions. ### Sacubitril Sacubitril is a **neprilysin inhibitor** that: - Inhibits the enzyme neprilysin. - Increases levels of beneficial natriuretic peptides. - Promotes sodium and water excretion. - Relaxes blood vessels. - Reduces stress on the heart. ### Valsartan Valsartan is an **angiotensin II receptor blocker (ARB)** that: - Blocks the action of angiotensin II. - Prevents narrowing of blood vessels. - Lowers blood pressure. - Reduces strain on the heart. - Helps decrease fluid retention associated with heart failure. Together, these actions improve heart function, reduce cardiac workload, and improve long-term outcomes in patients with HFrEF. --- # Dosage & Administration Always take **Sacubitril 24 mg + Valsartan 26 mg** exactly as prescribed by your healthcare provider. ### General Guidelines - Swallow the tablet whole with water. - Can be taken with or without food. - Take the medicine at the same time each day. - Do not crush or chew the tablet unless advised. - Follow your prescribed dosing schedule carefully. - Dose adjustments may be required based on blood pressure, kidney function, and overall response to treatment. ### Important Advice - If switching from an **ACE inhibitor**, a **36-hour washout period** is generally required before starting Sacubitril/Valsartan to reduce the risk of angioedema. - Continue taking the medicine even if you feel well unless your healthcare provider advises otherwise. ### Missed Dose - Take the missed dose as soon as you remember. - If it is almost time for the next dose, skip the missed dose. - Do not take two doses together. --- # Side Effects Like all medicines, Sacubitril + Valsartan may cause side effects, although not everyone experiences them. ## Common Side Effects - Low blood pressure (hypotension) - Dizziness - Fatigue - Cough - Elevated potassium levels - Kidney function changes - Headache ## Less Common Side Effects - Nausea - Diarrhea - Weakness - Light-headedness - Fainting ## Serious Side Effects (Seek Immediate Medical Attention) - Angioedema (swelling of the face, lips, tongue, or throat) - Severe allergic reactions - Difficulty breathing - Severe hypotension - Significant reduction in urine output - Severe kidney impairment - Dangerous elevations in blood potassium causing abnormal heart rhythm --- # Precautions & Warnings Before taking this medicine, inform your healthcare provider if you: - Have kidney disease. - Have liver disease. - Have low blood pressure. - Have high potassium levels. - Have diabetes. - Have previously experienced angioedema. - Are taking ACE inhibitors or ARBs. - Are pregnant, planning pregnancy, or breastfeeding. ### Important Warnings - **Do not use during pregnancy**, as it may cause serious harm to the unborn baby. - Do not take this medicine together with an ACE inhibitor. - Blood pressure, kidney function, and potassium levels should be monitored regularly. - Rise slowly from sitting or lying positions to reduce dizziness. - Avoid potassium supplements or salt substitutes containing potassium unless advised by your healthcare provider. - Seek immediate medical attention if swelling of the face or throat develops. --- # Drug Interactions Sacubitril + Valsartan may interact with: ### Blood Pressure Medicines - ACE inhibitors (e.g., enalapril, lisinopril) - Other ARBs - Aliskiren - Diuretics ### Medicines Affecting Potassium - Potassium supplements - Potassium-sparing diuretics (e.g., spironolactone, eplerenone) - Salt substitutes containing potassium ### Other Medicines - NSAIDs (e.g., ibuprofen, naproxen) - Lithium - Other antihypertensive medicines - Certain medicines affecting kidney function Always inform your healthcare provider about all prescription medicines, over-the-counter products, vitamins, and herbal supplements you are taking. --- # Storage Information - Store below **30°C** in a cool, dry place. - Protect from moisture and direct sunlight. - Keep the tablets in the original packaging. - Keep out of reach of children. - Do not use after the expiry date. --- # Prescription Status **Prescription Only Medicine (Rx)** Sacubitril 24 mg + Valsartan 26 mg should only be used under the supervision of a qualified healthcare professional, preferably a cardiologist or physician experienced in heart failure management. --- # Genuine Medicine Assurance We provide **100% genuine, quality-assured medicines** sourced from authorized pharmaceutical manufacturers and licensed distributors. Every product is stored and handled according to recommended pharmaceutical standards to help maintain its quality, safety, and effectiveness. --- # Frequently Asked Questions (FAQ) ## 1. What is Sacubitril 24 mg + Valsartan 26 mg used for? It is primarily used to treat chronic heart failure with reduced ejection fraction (HFrEF) and to reduce the risk of hospitalization and cardiovascular death in eligible patients. ## 2. How does Sacubitril + Valsartan work? Sacubitril increases beneficial heart-protective peptides, while Valsartan blocks angiotensin II, helping relax blood vessels, lower blood pressure, reduce fluid retention, and improve heart function. ## 3. Is Sacubitril + Valsartan a blood pressure medicine? It lowers blood pressure, but its primary indication is the treatment of chronic heart failure with reduced ejection fraction. ## 4. Can I take Sacubitril + Valsartan with an ACE inhibitor? No. It should not be taken together with an ACE inhibitor. A **36-hour washout period** is generally required when switching from an ACE inhibitor. ## 5. Can this medicine cause dizziness? Yes. Low blood pressure may cause dizziness or light-headedness, especially when starting treatment or increasing the dose. ## 6. Does Sacubitril + Valsartan improve survival in heart failure? Yes. Clinical studies have shown that it reduces the risk of cardiovascular death and heart failure-related hospitalization in appropriate patients with HFrEF. ## 7. Can this medicine affect kidney function? Yes. Kidney function should be monitored regularly during treatment, particularly in patients with pre-existing kidney disease. ## 8. Can I take potassium supplements while using this medicine? Only if advised by your healthcare provider. This medicine may increase blood potassium levels, and additional potassium could raise the risk of hyperkalemia. ## 9. Is Sacubitril + Valsartan safe during pregnancy? No. It should not be used during pregnancy because it may cause serious harm to the developing baby. ## 10. Can I stop taking this medicine if I feel better? No. Continue taking it as prescribed unless your healthcare provider instructs you to stop. ## 11. What should I do if I miss a dose? Take the missed dose when remembered unless it is almost time for your next scheduled dose. Do not double the dose. ## 12. Can I drink alcohol while taking this medicine? Alcohol may increase dizziness and lower blood pressure. Discuss alcohol use with your healthcare provider. ## 13. How should I store Sacubitril + Valsartan tablets? Store below 30°C in a cool, dry place, protected from moisture and direct sunlight, and keep out of reach of children. ## 14. When should I seek immediate medical attention? Seek emergency medical care if you develop swelling of the face or throat, difficulty breathing, severe dizziness, fainting, significantly reduced urine output, or signs of a severe allergic reaction. --- # Medical Disclaimer The information provided on this page is intended for **educational and informational purposes only** and should not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. **Sacubitril 24 mg + Valsartan 26 mg** should only be used as prescribed by a licensed healthcare professional. Seek immediate medical attention if you experience severe side effects, angioedema, allergic reactions, or symptoms of worsening heart failure. ```