INFECT-V

# Clotrimazole 100 mg + Lactic Acid 150 Million Cells + Metronidazole 500 mg ## Short Description **Clotrimazole 100 mg + Lactic Acid 150 Million Cells + Metronidazole 500 mg** is a combination **vaginal medicine** used for the treatment of certain vaginal infections involving **fungal and bacterial organisms**. * **Clotrimazole** is an antifungal medicine that targets *Candida* species. * **Metronidazole** is an antimicrobial medicine effective against certain anaerobic bacteria and protozoal infections. * **Lactic acid-producing cells** are intended to help support the normal vaginal environment and vaginal flora. This combination may be useful when symptoms suggest a **mixed vaginal infection**, but the exact diagnosis should be established by a healthcare professional. --- ## Key Benefits * Helps treat **vaginal fungal infections** caused by susceptible *Candida* species. * Provides antibacterial/antiprotozoal activity through metronidazole. * May help address **mixed vaginal infections** involving more than one type of organism. * Lactic acid-producing organisms may help support a healthy vaginal environment. * Can help reduce symptoms such as **itching, irritation, abnormal discharge and unpleasant vaginal odor** when these symptoms are caused by susceptible infections. * Provides multiple actions in a single vaginal formulation. --- ## Uses / Indications This combination may be used for vaginal infections such as: ### 1. Vaginal Candidiasis Clotrimazole treats fungal infections caused by susceptible *Candida* species. Common symptoms include: * Vaginal itching * Burning * Redness * Soreness * Thick or abnormal vaginal discharge ### 2. Bacterial Vaginosis Metronidazole is active against organisms associated with bacterial vaginosis. Typical symptoms may include: * Thin vaginal discharge * Unpleasant or fishy odor * Vaginal irritation ### 3. Trichomoniasis Metronidazole is effective against ***Trichomonas vaginalis*** when appropriately prescribed. **Important:** Trichomoniasis is a sexually transmitted infection. Sexual partners generally require evaluation and treatment to prevent reinfection. ### 4. Mixed Vaginal Infections The combination may be prescribed when both fungal and bacterial/protozoal components are suspected or confirmed. > Not every vaginal infection requires all three components. Diagnosis is important because vaginal itching or discharge can have several different causes. --- ## How It Works ### Clotrimazole Clotrimazole is an **azole antifungal**. It interferes with the production of **ergosterol**, an essential component of fungal cell membranes. This damages the fungal cell membrane and inhibits fungal growth. ### Metronidazole Metronidazole is converted into active compounds within susceptible anaerobic microorganisms and protozoa. These compounds damage microbial DNA, resulting in inhibition and death of susceptible organisms. ### Lactic Acid-Producing Cells The lactic acid-producing component is intended to support the normal vaginal environment. Lactobacilli naturally contribute to an acidic vaginal pH that can help discourage the overgrowth of certain unwanted microorganisms. ### Simple Mechanism **Clotrimazole → targets fungi** **Metronidazole → targets susceptible anaerobic bacteria/protozoa** **Lactic acid-producing cells → support the vaginal microbial environment** --- ## Dosage & Administration > **Use only according to the product packaging or prescription. Vaginal combination products can have different dosing schedules depending on their formulation.** For products containing **clotrimazole 100 mg + metronidazole 500 mg**, treatment is commonly administered as a **vaginal tablet/pessary inserted into the vagina**, often once daily for a prescribed course. ### General Administration 1. Wash your hands before and after application. 2. Insert the vaginal tablet/pessary **deep into the vagina** as directed. 3. Preferably administer it at bedtime if instructed, as this can reduce leakage. 4. Complete the full treatment course even if symptoms improve. 5. Do not take the vaginal preparation by mouth. ### During Menstruation Follow the specific product instructions regarding treatment during menstruation. In some cases, treatment may be scheduled to avoid menstrual bleeding. ### Important Do not use more frequently or for longer than prescribed. If symptoms do not improve after completing treatment, or if they return repeatedly, consult a healthcare professional. --- ## Side Effects ### Common Side Effects Possible effects include: * Vaginal irritation * Burning or stinging * Itching * Vaginal discomfort * Increased vaginal discharge * Abdominal discomfort * Nausea * Headache Some local irritation may occur shortly after insertion. ### Metronidazole-Related Effects Depending on systemic absorption, some people may experience: * Nausea * Metallic taste * Headache * Dizziness * Stomach discomfort ### Serious Side Effects Seek medical attention for: * Severe allergic reaction * Facial or throat swelling * Difficulty breathing * Severe rash * Significant vaginal swelling or irritation * Severe abdominal pain * Numbness or tingling of the hands or feet * Seizures or other unusual neurological symptoms --- ## Precautions & Warnings ### Correct Diagnosis Not all vaginal discharge or itching is caused by fungal or bacterial infection. Conditions such as sexually transmitted infections, hormonal changes, dermatitis and other vaginal disorders can cause similar symptoms. ### Avoid Self-Treatment for Recurrent Symptoms Repeated use without diagnosis may delay appropriate treatment. ### Pregnancy Consult your healthcare professional before using this combination during pregnancy. Vaginal medicines may be used during pregnancy when clinically appropriate, but the **method of insertion and timing of treatment should be determined by a healthcare professional**. ### Breastfeeding Ask your doctor before use while breastfeeding, particularly if repeated or prolonged treatment is required. ### Metronidazole and Alcohol Because this product contains metronidazole, many clinicians recommend **avoiding alcohol during treatment and for at least 48 hours after the final dose**, although the strength of evidence for a disulfiram-like interaction is debated. Follow the specific product information and your healthcare professional's advice. ### Sexual Activity For some vaginal infections, sexual activity may worsen irritation or contribute to reinfection. If the infection is **trichomoniasis**, sexual partners should be evaluated and treated as appropriate. ### Latex Products Some vaginal preparations may affect the integrity of **latex condoms or diaphragms**, depending on their excipients. Check the specific product leaflet and consider alternative contraception during treatment if recommended. ### Avoid Vaginal Irritants Avoid: * Douching * Perfumed vaginal products * Harsh soaps * Unnecessary vaginal cleansing products These can disturb the normal vaginal environment. --- ## Drug Interactions Because this is a vaginal preparation, systemic exposure may be lower than with oral metronidazole, but interactions can still be clinically relevant. ### Warfarin Metronidazole can increase the effect of **warfarin**, potentially increasing bleeding risk. Patients taking warfarin should consult their healthcare professional before treatment. ### Lithium Metronidazole may increase lithium concentrations in some patients. ### Certain Antiseizure Medicines Medicines that affect hepatic enzyme activity may alter metronidazole concentrations. ### Other Metronidazole Products Avoid unnecessary simultaneous use of other metronidazole-containing medicines unless prescribed. ### Alcohol Avoid alcohol during treatment and follow the product-specific advice regarding how long to wait after treatment. ### Other Vaginal Medicines Do not use multiple intravaginal products simultaneously unless recommended by a healthcare professional. > Always tell your doctor or pharmacist about all prescription medicines, OTC medicines, vitamins and herbal supplements you take. --- ## Storage Information * Store according to the manufacturer's instructions. * Keep at the recommended temperature. * Protect from excessive heat and moisture. * Keep the packaging tightly closed. * Protect vaginal tablets/pessaries from moisture. * Keep out of reach of children. * Do not use after the expiry date. * Keep the product in its original packaging until use. --- ## Prescription Status **Prescription status varies by country and formulation.** Some vaginal preparations containing clotrimazole may be available without a prescription, while combinations containing **metronidazole** may require a prescription or pharmacist-controlled dispensing. Follow local medicines regulations and use the product only as directed. --- ## Genuine Medicine Assurance When purchasing **Clotrimazole 100 mg + Lactic Acid 150 Million Cells + Metronidazole 500 mg**: * Purchase from a **licensed and reputable pharmacy**. * Verify all active ingredients and their stated strengths. * Check the manufacturer's name and regulatory information. * Verify the batch/lot number and expiry date. * Ensure the blister/package is sealed and undamaged. * Confirm that the product is intended for **vaginal use**. * Do not take a vaginal tablet orally. * Avoid products with suspicious packaging or altered labels. * Purchase only from authorized medicine suppliers. * If counterfeit medicine is suspected, contact the manufacturer, licensed pharmacy or relevant medicines regulatory authority. --- # Frequently Asked Questions (FAQ) ### 1. What is Clotrimazole 100 mg + Metronidazole 500 mg used for? It is a vaginal combination used for certain **fungal, bacterial and protozoal vaginal infections**, including mixed infections when appropriate. ### 2. What is the role of Clotrimazole? Clotrimazole is an antifungal medicine that treats susceptible ***Candida*** infections. ### 3. What is the role of Metronidazole? Metronidazole treats susceptible **anaerobic bacteria and protozoa**, including organisms associated with bacterial vaginosis and *Trichomonas vaginalis*. ### 4. Why are lactic acid-producing cells included? They are intended to help support the **normal vaginal microbial environment** and maintain conditions that favor healthy vaginal flora. ### 5. Can this medicine treat a yeast infection? Yes, the clotrimazole component is specifically active against susceptible vaginal yeast infections. ### 6. Can this medicine treat bacterial vaginosis? The metronidazole component is active against organisms associated with bacterial vaginosis, making the combination potentially useful when bacterial vaginosis is diagnosed and the formulation is appropriate. ### 7. Can this medicine treat trichomoniasis? Metronidazole is an effective treatment for trichomoniasis, but **medical diagnosis and appropriate treatment are important**. Sexual partners generally require evaluation and treatment as well. ### 8. How is this medicine administered? It is generally administered **intravaginally as a vaginal tablet or pessary**, according to the specific product instructions. ### 9. Can I swallow the vaginal tablet? **No.** A vaginal tablet/pessary is intended for insertion into the vagina and should not be swallowed. ### 10. How long does treatment usually last? Treatment duration varies according to the specific formulation and infection. Follow the prescribed course rather than stopping when symptoms improve. ### 11. Can I use this medicine during pregnancy? Use during pregnancy should be discussed with a healthcare professional. If treatment is appropriate, the clinician can advise on the safest method of vaginal administration. ### 12. Can I use it while breastfeeding? Consult your healthcare professional before use during breastfeeding, especially for repeated or prolonged treatment. ### 13. Should I avoid alcohol while using this medicine? Because the combination contains metronidazole, it is generally prudent to **avoid alcohol during treatment and for at least 48 hours afterward**, unless your healthcare professional or product information provides different instructions. ### 14. Can this medicine cause vaginal irritation? Yes. Temporary burning, itching or irritation can occur after vaginal application. ### 15. Can I have sex while using this medicine? Sexual activity may worsen vaginal irritation. If treating trichomoniasis or another sexually transmitted infection, follow your healthcare professional's advice regarding sexual activity and partner treatment. ### 16. Can this medicine prevent vaginal infections? No. It is intended to **treat specific infections**, not to routinely prevent them. ### 17. What if my symptoms do not improve? If symptoms persist after completing treatment, become worse or return frequently, consult a healthcare professional. You may have a different infection or require additional treatment. ### 18. Can I use other vaginal products at the same time? Do not use other vaginal medicines, douches or cleansing products unless specifically recommended by your healthcare professional. ### 19. Can this medicine treat all vaginal discharge? No. Vaginal discharge can have many causes. Proper diagnosis is important before selecting treatment. ### 20. Is Clotrimazole + Metronidazole available without a prescription? Availability varies by country and formulation. Products containing metronidazole may require a prescription or pharmacist supervision in many markets. --- ## Medical Disclaimer This information about **Clotrimazole 100 mg + Lactic Acid 150 Million Cells + Metronidazole 500 mg** is provided for educational and general informational purposes only. It is **not a substitute for professional medical advice, diagnosis or treatment**. Vaginal itching, discharge, odor and irritation can have multiple causes, and inappropriate self-treatment may delay correct diagnosis. **Trichomoniasis and other sexually transmitted infections require appropriate medical evaluation and partner management.** Pregnant patients, breastfeeding patients, people with recurrent vaginal infections and those taking medicines such as warfarin or lithium should consult a healthcare professional before use. **Always follow the specific product label and your healthcare professional's instructions.**