LINTAB-M 500

# Linagliptin 2.5 mg + Metformin Hydrochloride 500 mg ## SHORT DESCRIPTION Linagliptin 2.5 mg + Metformin Hydrochloride 500 mg is a combination oral antidiabetic medicine used to help control blood sugar levels in adults with **type 2 diabetes mellitus**. It combines two medicines with complementary actions: linagliptin, a DPP-4 inhibitor, and metformin, a biguanide. It is generally used along with a healthy diet and regular physical activity. It is **not used to treat type 1 diabetes or diabetic ketoacidosis**. ## KEY BENEFITS * Helps improve blood glucose control in adults with type 2 diabetes * Combines two complementary blood sugar-lowering medicines * Helps reduce elevated blood glucose levels throughout the day * Linagliptin has a relatively low risk of causing hypoglycemia when used alone * Metformin helps improve the body's response to insulin * Convenient combination therapy may reduce the need to take separate tablets ## USES / INDICATIONS Linagliptin 2.5 mg + Metformin Hydrochloride 500 mg may be prescribed for: * Type 2 diabetes mellitus * Improving blood glucose control when diet and exercise alone are insufficient * Patients requiring treatment with both linagliptin and metformin * Patients whose blood sugar is not adequately controlled with one of these medicines alone, depending on the doctor's assessment **It is not indicated for type 1 diabetes or diabetic ketoacidosis.** ## HOW IT WORKS ### Linagliptin Linagliptin is a **DPP-4 inhibitor**. It prevents the breakdown of incretin hormones, which helps increase insulin release when blood glucose is elevated and reduce the release of glucagon. This helps lower blood glucose levels. ### Metformin Metformin reduces glucose production by the liver and improves insulin sensitivity, allowing the body to use glucose more effectively. Together, these medicines help control blood glucose through complementary mechanisms. ## DOSAGE & ADMINISTRATION * Take this medicine exactly as prescribed by your doctor. * The appropriate dose depends on your blood glucose levels, kidney function, previous diabetes treatment, and individual response. * Take the tablet **with meals** to reduce the likelihood of stomach-related side effects from metformin. * Swallow the tablet whole with water unless your specific product instructions state otherwise. * Take it at approximately the same time each day. * Do not change the dose or stop treatment without consulting your doctor. * Regular blood glucose monitoring may be recommended. * If you miss a dose, take it when remembered unless it is nearly time for your next dose. Do not take a double dose. **Important:** The stated strength of **linagliptin 2.5 mg + metformin 500 mg** should be checked against the product label because combination products are available in different strengths and formulations. ## SIDE EFFECTS ### Common Side Effects * Diarrhea * Nausea * Vomiting * Stomach discomfort * Abdominal pain * Loss of appetite * Headache * Metallic taste or changes in taste Gastrointestinal effects are particularly common when starting metformin and may improve as the body adjusts. ### Serious Side Effects Seek medical attention promptly if you develop: * Severe or persistent abdominal pain * Severe weakness, unusual tiredness, or difficulty breathing * Persistent vomiting * Signs of dehydration * Severe allergic reaction such as swelling of the face, lips, tongue, or throat * Severe skin rash or blistering * Symptoms of pancreatitis such as persistent severe abdominal pain that may radiate to the back * Severe joint pain * Symptoms of low blood sugar, particularly when used with insulin or sulfonylureas **Lactic acidosis** is a rare but potentially life-threatening complication associated primarily with metformin. Symptoms can include extreme weakness, unusual muscle pain, difficulty breathing, unusual sleepiness, abdominal discomfort, dizziness, feeling cold, or a slow/irregular heartbeat. Seek emergency medical attention if these occur. ## PRECAUTIONS & WARNINGS Tell your doctor before using this medicine if you have: * Kidney disease or reduced kidney function * Liver disease * Heart failure or significant heart disease * A history of pancreatitis * Gallbladder disease * Heavy or excessive alcohol consumption * Vitamin B12 deficiency * A history of severe allergic reactions to diabetes medicines * A planned surgery or medical procedure requiring fasting ### Important Safety Information * Kidney function should be assessed before and during metformin-containing treatment. * Metformin may need to be temporarily stopped around certain procedures involving iodinated contrast media, depending on kidney function and the clinical situation. * Avoid excessive alcohol consumption because it can increase the risk of metformin-associated lactic acidosis. * Long-term metformin use may reduce vitamin B12 levels. * Linagliptin can rarely cause pancreatitis. * Hypoglycemia is more likely when this combination is used with insulin or a sulfonylurea. * Do not use this medicine for type 1 diabetes or diabetic ketoacidosis. * Inform your doctor if you become pregnant or plan to become pregnant. ## DRUG INTERACTIONS Linagliptin + Metformin may interact with certain medicines, including: * **Insulin and sulfonylureas** — may increase the risk of hypoglycemia. * **Rifampicin and other strong enzyme inducers** — may reduce the effectiveness of linagliptin. * **Iodinated contrast media** — may require temporary interruption of metformin in certain circumstances. * **Cimetidine** — may affect metformin clearance. * **Certain diuretics and medicines affecting kidney function** — may alter metformin safety. * **Corticosteroids** — may increase blood glucose levels. * **Some blood pressure medicines and other medications** can affect glucose control. Always tell your doctor or pharmacist about all prescription medicines, over-the-counter medicines, vitamins, and herbal supplements you take. ## STORAGE INFORMATION * Store according to the instructions on the product packaging. * Keep the tablets in their original container. * Protect from excessive heat, moisture, and direct light. * Keep out of the sight and reach of children. * Do not use after the expiry date printed on the package. * Do not use tablets if the packaging is damaged or the medicine appears abnormal. ## PRESCRIPTION STATUS **Prescription Medicine** Linagliptin 2.5 mg + Metformin Hydrochloride 500 mg should be used under the supervision of a qualified healthcare professional. ## GENUINE MEDICINE ASSURANCE When purchasing Linagliptin + Metformin: * Purchase from a licensed and reputable pharmacy. * Check that the packaging is sealed and intact. * Verify the medicine name, strength, batch number, and expiry date. * Ensure the product is stored according to the manufacturer's requirements. * Avoid products with suspicious, damaged, or altered packaging. * Consult a pharmacist if you have concerns about the authenticity or quality of the medicine. ## FAQ — FREQUENTLY ASKED QUESTIONS ### What is Linagliptin 2.5 mg + Metformin 500 mg used for? It is used with diet and exercise to help control blood sugar in adults with type 2 diabetes mellitus. ### Is Linagliptin + Metformin used for type 1 diabetes? No. This combination is not indicated for the treatment of type 1 diabetes or diabetic ketoacidosis. ### What does Linagliptin do? Linagliptin is a DPP-4 inhibitor that helps increase glucose-dependent insulin release and decrease glucagon release, helping lower blood glucose levels. ### What does Metformin do? Metformin reduces glucose production by the liver and improves the body's sensitivity to insulin, helping the body use glucose more effectively. ### Can Linagliptin and Metformin be taken together? Yes. They are specifically combined in some medicines because they work through different mechanisms to improve blood glucose control. ### Should Linagliptin + Metformin be taken with food? Taking the combination with meals can help reduce gastrointestinal side effects associated with metformin. Follow the instructions provided for your specific product. ### Can Linagliptin + Metformin cause low blood sugar? By themselves, these medicines generally have a relatively low risk of hypoglycemia. However, the risk can increase when they are combined with insulin or sulfonylureas. ### Can Linagliptin + Metformin cause stomach problems? Yes. Diarrhea, nausea, abdominal discomfort, and other gastrointestinal symptoms can occur, especially when starting metformin. These effects may improve over time. ### Can Linagliptin + Metformin affect the kidneys? Metformin is eliminated through the kidneys, so kidney function is important when using this medicine. Your doctor may check kidney function before and during treatment. ### Can Metformin cause vitamin B12 deficiency? Yes. Long-term metformin treatment can reduce vitamin B12 levels in some people. Your doctor may recommend monitoring B12 levels, particularly if you have symptoms or risk factors for deficiency. ### Can Linagliptin cause pancreatitis? Pancreatitis is a rare but potentially serious adverse effect associated with linagliptin. Seek medical attention for persistent severe abdominal pain, especially if it radiates to the back. ### Can I stop Linagliptin + Metformin when my blood sugar improves? Do not stop the medicine without medical advice. Improved blood glucose may indicate that the treatment, diet, and lifestyle measures are working. Your doctor should determine whether the treatment should be continued or adjusted. ### What should I do if I miss a dose? Take the missed dose when you remember unless it is nearly time for your next dose. Do not take two doses together to make up for a missed dose. ### Is Linagliptin + Metformin available without a prescription? It is generally a prescription medicine and should be used under the guidance of a qualified healthcare professional. ## MEDICAL DISCLAIMER This information is provided for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Linagliptin 2.5 mg + Metformin Hydrochloride 500 mg should be taken only as prescribed by a qualified healthcare professional. Diabetes treatment must be individualized based on blood glucose levels, kidney and liver function, other medicines, diet, lifestyle, and overall health. Do not start, stop, or change the dose without medical advice. Seek urgent medical attention for symptoms of severe hypoglycemia, lactic acidosis, pancreatitis, or a serious allergic reaction.