NOX-400

# Norfloxacin 400 mg ## SHORT DESCRIPTION Norfloxacin 400 mg is a **fluoroquinolone antibiotic** used to treat certain bacterial infections. It works by interfering with bacterial enzymes required for DNA replication, thereby stopping the growth and survival of susceptible bacteria. Norfloxacin should be used only when a bacterial infection is confirmed or strongly suspected and when the medicine is considered appropriate, as fluoroquinolone antibiotics can cause potentially serious adverse effects. ## KEY BENEFITS * Helps treat certain **susceptible bacterial infections** * Effective against various Gram-negative bacteria * Commonly used for selected **urinary tract infections** * May be prescribed for certain bacterial gastrointestinal infections * Inhibits bacterial growth and replication * Convenient oral tablet formulation ## USES / INDICATIONS Norfloxacin 400 mg may be prescribed for certain susceptible bacterial infections, including: * **Urinary tract infections (UTIs)** * Certain bacterial gastrointestinal infections * Infectious diarrhea caused by susceptible bacteria * Other infections when bacterial susceptibility and local treatment guidelines support its use Norfloxacin is **not effective against viral infections** such as the common cold or influenza. ## HOW IT WORKS Norfloxacin belongs to the **fluoroquinolone** class of antibiotics. It inhibits bacterial enzymes called **DNA gyrase and topoisomerase IV**. These enzymes are necessary for bacterial DNA replication and repair. By blocking these enzymes, norfloxacin interferes with bacterial multiplication and can cause the death of susceptible bacteria. ## DOSAGE & ADMINISTRATION * Take Norfloxacin 400 mg exactly as prescribed by your doctor. * A commonly used adult regimen for certain infections is **400 mg twice daily**, but the appropriate dose and duration depend on the infection and patient factors. * Take the tablet with a full glass of water. * Norfloxacin is generally taken **on an empty stomach**, approximately 1 hour before or 2 hours after food. * Avoid taking it at the same time as milk or dairy products because calcium can reduce absorption. * Complete the prescribed course unless your healthcare professional tells you to stop. * Do not use leftover antibiotics for another illness. ### Important Administration Information Separate norfloxacin from products containing **calcium, magnesium, aluminum or iron**, including many antacids and mineral supplements, because they can significantly reduce antibiotic absorption. Follow your pharmacist's instructions regarding the appropriate interval. ### Missed Dose Take the missed dose when remembered unless it is nearly time for the next dose. Do not take two doses together. ## SIDE EFFECTS Common side effects may include: * Nausea * Diarrhea * Abdominal discomfort * Headache * Dizziness * Heartburn * Vomiting ### Serious Side Effects Stop taking the medicine and seek medical attention promptly if you experience: * **Pain, swelling or inflammation of a tendon** * Tendon rupture, particularly involving the Achilles tendon * Numbness, tingling, burning or weakness * Severe muscle or joint pain * Severe or persistent diarrhea * Severe allergic reaction * Significant mood or behavioral changes * Confusion, hallucinations or seizures * Fast or irregular heartbeat * Severe skin reaction * Symptoms of liver injury such as yellowing of the skin or eyes Fluoroquinolones can rarely cause **long-lasting or potentially irreversible effects involving tendons, muscles, joints, nerves and the central nervous system**. ## PRECAUTIONS & WARNINGS * Do not use norfloxacin if you have previously experienced a serious reaction to a fluoroquinolone. * Fluoroquinolones may cause **tendonitis and tendon rupture**, particularly in older adults and people taking corticosteroids. * Avoid strenuous physical activity if tendon pain or swelling develops. * Tell your doctor if you have a history of tendon problems. * Inform your doctor if you have **kidney disease**, as dosage adjustment may be required. * Tell your doctor if you have heart rhythm problems or conditions that can cause low potassium or magnesium. * Use caution if you have a history of seizures or neurological disorders. * Norfloxacin can occasionally cause significant changes in blood glucose, particularly in people with diabetes. * Avoid unnecessary exposure to strong sunlight or UV radiation if you develop photosensitivity. * Stop the medicine and seek medical advice if severe or persistent diarrhea develops. * Do not use for viral infections. * Older adults may have an increased risk of tendon and other fluoroquinolone-related adverse effects. * Tell your doctor if you are pregnant, planning pregnancy or breastfeeding. * Do not drive or operate machinery if you experience dizziness or impaired alertness. ## DRUG INTERACTIONS Norfloxacin can interact with several medicines and supplements, including: * **Antacids containing aluminum or magnesium** — can substantially reduce norfloxacin absorption. * **Iron supplements** — can reduce absorption. * **Calcium supplements** — can reduce absorption. * **Zinc supplements** — may reduce absorption. * **Sucralfate** — can reduce absorption. * **Milk and dairy products** — calcium can decrease absorption when taken together. * **Warfarin** — anticoagulant effects may be altered and monitoring may be required. * **Certain medicines that prolong the QT interval** — may increase the risk of abnormal heart rhythms. * **Corticosteroids** — may increase the risk of tendon injury. * Certain diabetes medicines — blood glucose levels may be affected. * **NSAIDs** may potentially increase the risk of central nervous system stimulation or seizures in susceptible individuals. Always tell your doctor or pharmacist about all prescription medicines, over-the-counter medicines, supplements and herbal products you take. ## STORAGE INFORMATION * Store according to the manufacturer's instructions. * Keep the tablets in their original packaging. * Store at the recommended room temperature. * Protect from excessive heat, moisture and direct sunlight. * Keep out of reach of children. * Do not use after the expiry date. * Do not use the medicine if the packaging is damaged. ## PRESCRIPTION STATUS **Prescription medicine.** Norfloxacin 400 mg should be used only under the supervision of a qualified healthcare professional. Its use should be based on appropriate clinical assessment and local antibiotic-resistance recommendations. ## GENUINE MEDICINE ASSURANCE For safe and genuine Norfloxacin 400 mg: * Purchase only from a licensed and reputable pharmacy. * Check the medicine name and strength. * Verify the manufacturer's details. * Check the batch number and expiry date. * Check the expiry date before use. * Ensure the packaging and seal are intact. * Avoid medicines with damaged or suspicious packaging. * Do not purchase antibiotics from unauthorized sources. * Consult a pharmacist if you have concerns about product authenticity. ## FAQ ### What is Norfloxacin 400 mg used for? Norfloxacin 400 mg is a fluoroquinolone antibiotic used for certain **susceptible bacterial infections**, particularly selected urinary tract and gastrointestinal infections. ### Is Norfloxacin an antibiotic? Yes. Norfloxacin is a **fluoroquinolone antibiotic**. ### How does Norfloxacin work? It blocks bacterial enzymes called **DNA gyrase and topoisomerase IV**, preventing bacteria from replicating and repairing their DNA. ### Can Norfloxacin treat a UTI? Yes. Norfloxacin may be prescribed for certain urinary tract infections caused by susceptible bacteria. However, antibiotic selection should consider current resistance patterns and the specific infection. ### Can Norfloxacin treat diarrhea? It may be used for certain **bacterial gastrointestinal infections**, but it is not appropriate for every type of diarrhea. Many cases of diarrhea are viral or do not require antibiotics. ### Can Norfloxacin treat a cold or flu? No. Norfloxacin does not treat viral infections such as colds or influenza. ### Should Norfloxacin 400 mg be taken with food? Norfloxacin is generally taken **on an empty stomach**, approximately 1 hour before or 2 hours after food, unless your specific product instructions say otherwise. ### Can I take Norfloxacin with milk? It is generally recommended to avoid taking norfloxacin together with milk or dairy products because calcium can reduce its absorption. ### Can I take calcium with Norfloxacin? Calcium can reduce norfloxacin absorption. Calcium supplements should generally be separated from norfloxacin according to your doctor's or pharmacist's instructions. ### Can I take iron supplements with Norfloxacin? Iron can significantly reduce norfloxacin absorption. Take iron and norfloxacin at appropriately separated times as advised by your healthcare professional. ### Can I take antacids with Norfloxacin? Antacids containing aluminum or magnesium can reduce norfloxacin absorption. They should be separated from norfloxacin by an appropriate interval. ### What are the common side effects of Norfloxacin? Common side effects include **nausea, diarrhea, abdominal discomfort, headache and dizziness**. ### Can Norfloxacin damage tendons? Yes. Fluoroquinolone antibiotics can cause **tendonitis and tendon rupture**, sometimes during treatment or after treatment has ended. The risk is higher in older adults and people taking corticosteroids. ### What should I do if I develop tendon pain while taking Norfloxacin? Stop strenuous physical activity and contact your healthcare professional promptly if you develop tendon pain, swelling or weakness. Medical evaluation may be necessary. ### Can Norfloxacin cause nerve problems? Rarely, fluoroquinolones can cause peripheral neuropathy, resulting in **pain, burning, tingling, numbness or weakness**. Seek medical advice promptly if these symptoms develop. ### Can Norfloxacin affect blood sugar? Yes. Fluoroquinolones can cause changes in blood glucose, including low or high blood sugar. People with diabetes should monitor glucose as advised. ### Can Norfloxacin affect the heart? Norfloxacin may contribute to **QT interval prolongation** in susceptible individuals. Tell your doctor if you have a heart rhythm disorder or take other medicines that affect the QT interval. ### Can Norfloxacin be taken during pregnancy? Norfloxacin is generally avoided during pregnancy unless a healthcare professional determines that it is necessary. Discuss pregnancy or plans for pregnancy with your doctor. ### Can Norfloxacin be taken while breastfeeding? Fluoroquinolone use during breastfeeding should be discussed with a healthcare professional, who can assess the benefits and potential risks. ### Can I drink alcohol while taking Norfloxacin? Alcohol does not have a specific major interaction with norfloxacin, but it may worsen dizziness or other side effects. Avoid alcohol if it makes you feel unwell or if your healthcare professional advises against it. ### What should I do if I miss a dose of Norfloxacin? Take the missed dose when you remember unless it is nearly time for the next dose. Do not take a double dose. ### What happens if I take too much Norfloxacin? Taking too much may increase the risk of adverse effects. Contact a healthcare professional or seek urgent medical attention if you have taken significantly more than prescribed. ### How long does Norfloxacin take to work? Some symptoms may improve within a few days if the bacteria are susceptible and the antibiotic is appropriate. Complete the prescribed course even if symptoms improve earlier. ### Does Norfloxacin cause antibiotic resistance? Yes, inappropriate or unnecessary use of antibiotics can contribute to **antibiotic resistance**. Norfloxacin should only be used when clinically appropriate and prescribed by a healthcare professional. ### How should Norfloxacin 400 mg be stored? Store it according to the manufacturer's instructions, generally at room temperature away from excessive heat and moisture. Keep it in its original packaging and out of reach of children. ## MEDICAL DISCLAIMER This information is provided for educational and informational purposes only and does not replace professional medical advice, diagnosis or treatment. **Norfloxacin 400 mg is a prescription fluoroquinolone antibiotic and should only be used when clinically appropriate for a susceptible bacterial infection.** Fluoroquinolones can cause potentially serious and sometimes long-lasting adverse effects involving tendons, nerves, muscles, joints and the nervous system. Seek medical attention for tendon pain or swelling, numbness or tingling, severe diarrhea, allergic reactions, significant mood changes or heart rhythm symptoms. Always follow the specific product label and your healthcare professional's instructions.