OLMAT-20 AM

# Amlodipine 5 mg + Olmesartan 20 mg ## SHORT DESCRIPTION **Amlodipine 5 mg + Olmesartan 20 mg** is a prescription combination medicine used primarily to treat **high blood pressure (hypertension)**. It combines a calcium-channel blocker, amlodipine, with an angiotensin II receptor blocker (ARB), olmesartan. The combination works through two complementary mechanisms to relax blood vessels and reduce blood pressure. It may be prescribed when treatment with one medicine alone does not adequately control blood pressure. ## KEY BENEFITS * Helps lower **high blood pressure** * Relaxes and widens blood vessels * Provides blood-pressure control through **two complementary mechanisms** * May help reduce the risk of complications associated with uncontrolled hypertension * Convenient once-daily combination therapy when prescribed appropriately * May improve blood-pressure control when a single medicine is insufficient ## USES / INDICATIONS Amlodipine 5 mg + Olmesartan 20 mg may be prescribed for: * **Hypertension** * Patients whose blood pressure is not adequately controlled with a single antihypertensive medicine * Patients who require combination treatment with a calcium-channel blocker and an ARB This medicine should be used together with appropriate lifestyle measures such as a healthy diet, regular physical activity, and reduced sodium intake where advised. ## HOW IT WORKS ### Amlodipine Amlodipine is a **calcium-channel blocker (CCB)**. It reduces the movement of calcium into the muscle cells of blood-vessel walls, causing the blood vessels to relax and widen. ### Olmesartan Olmesartan is an **angiotensin II receptor blocker (ARB)**. It blocks angiotensin II from binding to AT1 receptors. This reduces blood-vessel constriction and decreases the effects that promote sodium and fluid retention. ### Combined Action **Amlodipine → Relaxes blood-vessel muscle** **Olmesartan → Blocks angiotensin II → Reduces vasoconstriction** **Together → Wider blood vessels → Lower blood pressure** ## DOSAGE & ADMINISTRATION The dose should be determined by your healthcare professional based on your blood pressure and response to treatment. For adults, the commonly used combination strength is: * **Amlodipine 5 mg + Olmesartan 20 mg once daily** * Take exactly as prescribed. * It may be taken **with or without food**. * Take the tablet at approximately the same time every day. * Swallow it with water. * Continue treatment even if you feel well, unless your doctor tells you to stop. Your doctor may adjust the dose depending on blood-pressure control and tolerability. ### Missed Dose Take the missed dose when you remember unless it is nearly time for the next dose. **Do not take two doses at the same time.** ## SIDE EFFECTS Common side effects may include: * Dizziness * Headache * Fatigue * Flushing * Ankle or leg swelling * Palpitations * Nausea * Increased potassium levels * Low blood pressure **Ankle swelling (peripheral edema)** is a relatively common side effect associated with amlodipine. ### Serious Side Effects Seek medical attention if you experience: * Severe dizziness or fainting * Significant swelling of the face, lips, tongue, or throat * Difficulty breathing or swallowing * Severe or persistent weakness * Significant changes in urination * Symptoms suggesting a severe allergic reaction ## PRECAUTIONS & WARNINGS ### Pregnancy **Olmesartan should not be used during pregnancy.** Medicines that act on the renin-angiotensin system can cause serious fetal injury, particularly during the second and third trimesters. Contact your doctor immediately if you become pregnant while taking this medicine. ### Kidney Function Olmesartan can affect kidney function in some patients. Your doctor may monitor kidney function and blood potassium levels, especially if you have kidney disease or are dehydrated. ### High Potassium Olmesartan can increase potassium levels. Tell your doctor if you have: * Kidney disease * High blood potassium * Conditions affecting potassium balance * A history of abnormal potassium levels Do not use potassium supplements or potassium-containing salt substitutes unless recommended by your healthcare professional. ### Low Blood Pressure Dizziness or low blood pressure may occur, particularly when starting treatment, increasing the dose, or if you are dehydrated. ### Liver Disease Tell your healthcare professional if you have liver disease. Amlodipine and olmesartan may require careful dosing or monitoring in certain liver conditions. ### Dehydration Vomiting, diarrhea, excessive sweating, or inadequate fluid intake can increase the risk of low blood pressure and kidney problems. ### Heart Conditions Tell your doctor if you have heart failure, severe aortic stenosis, or other significant heart conditions before starting treatment. ### Breastfeeding Consult your healthcare professional before using this medicine while breastfeeding. An alternative treatment may be considered. ## DRUG INTERACTIONS This combination may interact with: * **Potassium supplements** * Potassium-containing salt substitutes * Potassium-sparing diuretics such as spironolactone * Other medicines that increase potassium * Other blood-pressure medicines * **NSAIDs**, such as ibuprofen, diclofenac, and naproxen * **Lithium** * Certain medicines that affect blood pressure or kidney function * Some medicines that may increase amlodipine levels ### Important Interaction Combining olmesartan with other medicines that act on the renin-angiotensin system may increase the risk of **low blood pressure, high potassium, and kidney problems** and should only be done under appropriate medical supervision. Always tell your doctor or pharmacist about all prescription medicines, over-the-counter medicines, vitamins, and herbal supplements you use. ## STORAGE INFORMATION * Store according to the manufacturer's instructions. * Keep at room temperature unless otherwise specified. * Protect from excessive heat, moisture, and direct sunlight. * Keep tablets in their original packaging. * Keep the container tightly closed. * Keep out of reach and sight of children. * Do not use after the expiry date. * Do not use tablets from damaged or improperly sealed packaging. ## PRESCRIPTION STATUS **Amlodipine 5 mg + Olmesartan 20 mg is generally a prescription medicine.** It should be used under the supervision of a qualified healthcare professional. Blood pressure, kidney function, and potassium levels may require monitoring in appropriate patients. ## GENUINE MEDICINE ASSURANCE To help ensure you receive genuine Amlodipine 5 mg + Olmesartan 20 mg: * Purchase from a licensed and reputable pharmacy. * Check the medicine name and strength. * Verify the manufacturer's details. * Check the batch number and expiry date. * Ensure the packaging is sealed and undamaged. * Confirm that the strength is **Amlodipine 5 mg + Olmesartan 20 mg**. * Avoid products with altered or suspicious packaging. * Purchase prescription medicines only from authorized sources. * Ask your pharmacist to verify the product if you have concerns about authenticity. ## FAQ SECTION ### What is Amlodipine 5 mg + Olmesartan 20 mg used for? It is primarily used to **treat high blood pressure (hypertension)**, particularly when one blood-pressure medicine alone does not provide adequate control. ### Is Amlodipine and Olmesartan a combination medicine? Yes. It combines **amlodipine**, a calcium-channel blocker, with **olmesartan**, an angiotensin II receptor blocker. ### How does Amlodipine 5 mg + Olmesartan 20 mg work? Amlodipine relaxes blood-vessel muscles, while olmesartan blocks the action of angiotensin II. Together, they help widen blood vessels and lower blood pressure. ### Is Amlodipine 5 mg + Olmesartan 20 mg used for hypertension? Yes. Hypertension is the main indication for this combination. ### When should I take Amlodipine and Olmesartan? It is usually taken **once daily**, at approximately the same time each day. It can generally be taken with or without food. ### Can I take Amlodipine and Olmesartan at night? It may generally be taken at any consistent time of day. Follow the timing recommended by your healthcare professional. ### Can Amlodipine and Olmesartan be taken with food? Yes. The combination can generally be taken **with or without food**. ### How long does Amlodipine + Olmesartan take to lower blood pressure? Blood pressure begins to respond after treatment starts, while the full effect may take several weeks. Your doctor may monitor your blood pressure and adjust treatment accordingly. ### Does Amlodipine + Olmesartan cure high blood pressure? It **controls high blood pressure** but does not cure the underlying tendency toward hypertension. Many people require long-term treatment. ### Can I stop Amlodipine + Olmesartan if my blood pressure becomes normal? Do not stop the medicine without consulting your doctor. Normal blood pressure may mean the treatment is working effectively. ### Does Amlodipine cause ankle swelling? Yes. **Ankle or leg swelling (peripheral edema)** is a known side effect of amlodipine. ### Does Olmesartan increase potassium? Yes. Olmesartan can increase potassium levels in some people, particularly those with kidney problems or those taking other potassium-raising medicines. ### Can I take potassium supplements with Olmesartan? Do not take potassium supplements or potassium-containing salt substitutes unless your doctor recommends them. ### Can Amlodipine + Olmesartan cause dizziness? Yes. Dizziness can occur because the combination lowers blood pressure, particularly when treatment is first started or the dose is increased. ### Can I take Amlodipine + Olmesartan with other blood-pressure medicines? Additional blood-pressure medicines may sometimes be prescribed, but this should be determined by your healthcare professional to avoid excessive blood-pressure reduction or other complications. ### Can I take Amlodipine + Olmesartan with ibuprofen? NSAIDs such as ibuprofen may interact with olmesartan and can increase the risk of kidney problems or reduce blood-pressure control, especially with prolonged use or dehydration. Consult your healthcare professional before regular NSAID use. ### Can Amlodipine + Olmesartan be used during pregnancy? No. Because it contains olmesartan, this combination **should not be used during pregnancy**. Contact your doctor promptly if pregnancy occurs while taking it. ### Can I take Amlodipine + Olmesartan while breastfeeding? Consult your healthcare professional before using this medicine while breastfeeding. An alternative medicine may be preferred. ### Does Amlodipine + Olmesartan cause weight gain? Significant weight gain is not a typical direct effect of this combination. However, swelling caused by fluid accumulation can sometimes result in an increase in body weight. ### Does Amlodipine + Olmesartan cause frequent urination? Frequent urination is not a primary expected effect because this combination does not contain a diuretic. Other causes should be considered if frequent urination occurs. ### What happens if I miss a dose? Take it when remembered unless it is nearly time for your next dose. Do not take two doses together. ### How long should I take Amlodipine 5 mg + Olmesartan 20 mg? Treatment duration depends on your blood-pressure control and overall health. Many patients require long-term therapy. ### How should Amlodipine 5 mg + Olmesartan 20 mg be stored? Store according to the manufacturer's instructions, generally at room temperature and away from excessive heat, moisture, and direct sunlight. Keep it out of reach of children. ## MEDICAL DISCLAIMER This information about **Amlodipine 5 mg + Olmesartan 20 mg** is provided for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. This is a prescription medicine and should be used according to a healthcare professional's recommendation. Particular caution is required in patients with **kidney disease, liver disease, heart conditions, low blood pressure, dehydration, or abnormal potassium levels**. **This medicine should not be used during pregnancy because it contains olmesartan.** Contact your healthcare professional immediately if pregnancy occurs during treatment. Do not change the dose or stop treatment without medical advice. Seek urgent medical attention for severe dizziness or fainting, swelling of the face or throat, difficulty breathing, or other serious symptoms. Always follow your doctor's prescription and the manufacturer's instructions regarding dosage, contraindications, precautions, drug interactions, monitoring, and duration of treatment.