OLMAT-40 AM

# AMLODIPINE 5 MG + OLMESARTAN 40 MG ## SHORT DESCRIPTION **Amlodipine 5 mg + Olmesartan 40 mg** is a combination antihypertensive medicine used to **lower high blood pressure (hypertension)**. It combines two medicines with different mechanisms: amlodipine, a calcium-channel blocker, relaxes blood vessels, while olmesartan, an angiotensin II receptor blocker (ARB), prevents blood vessels from tightening. By working together, these medicines can provide more effective blood-pressure control than either component alone in appropriate patients. --- ## KEY BENEFITS * Helps **lower high blood pressure**. * Relaxes and widens blood vessels. * Reduces resistance against blood flow. * Provides blood-pressure control through two complementary mechanisms. * May help reduce the long-term risk of complications associated with uncontrolled hypertension. * Convenient once-daily combination therapy when prescribed appropriately. --- ## USES / INDICATIONS Amlodipine 5 mg + Olmesartan 40 mg is primarily indicated for: * **Hypertension (high blood pressure)** * Patients requiring combination therapy to achieve adequate blood-pressure control. * Patients whose blood pressure remains inadequately controlled with amlodipine or olmesartan alone, when a healthcare professional considers combination treatment appropriate. Controlling hypertension can help reduce the risk of: * Stroke * Heart attack * Heart failure * Kidney complications * Other cardiovascular complications --- ## HOW IT WORKS ### Amlodipine Amlodipine is a **calcium-channel blocker (CCB)**. It reduces the movement of calcium into vascular smooth muscle cells, causing the arteries to relax and widen. This reduces peripheral resistance and lowers blood pressure. ### Olmesartan Olmesartan is an **angiotensin II receptor blocker (ARB)**. It blocks the action of angiotensin II, a hormone that causes blood vessels to constrict and contributes to sodium and water retention. Blocking angiotensin II causes blood vessels to relax and helps reduce blood pressure. ### Combined Action **Amlodipine relaxes the arteries + Olmesartan blocks angiotensin II → improved blood-pressure control.** --- ## DOSAGE & ADMINISTRATION Take this medicine exactly as prescribed by your healthcare professional. ### General Directions * The combination is commonly taken **once daily**. * Take it at approximately the same time each day. * It can generally be taken **with or without food**. * Swallow the tablet with water. * Do not change the dose without medical advice. The **5 mg/40 mg strength** should be used according to the individual treatment plan and blood-pressure response. ### Missed Dose If you forget a dose, take it when you remember unless it is close to the next scheduled dose. **Do not take a double dose** to compensate for a missed dose. ### Important Continue treatment even if you feel well unless your healthcare professional tells you to stop. High blood pressure often has **no obvious symptoms**. --- ## SIDE EFFECTS ### Common Side Effects Possible side effects include: * Dizziness * Headache * Fatigue * Flushing * Palpitations * Nausea * Mild gastrointestinal discomfort * Swelling of the ankles or feet **Peripheral edema (ankle swelling)** is a recognized side effect of amlodipine. ### Olmesartan-Related Effects Olmesartan may cause: * Dizziness * Low blood pressure * Increased blood potassium * Changes in kidney function Rarely, olmesartan can cause severe, persistent diarrhea with weight loss due to a condition known as **sprue-like enteropathy**. ### Seek Medical Attention For Contact a healthcare professional urgently if you experience: * Fainting or severe dizziness * Severe swelling of the face, lips, tongue, or throat * Difficulty breathing * Markedly reduced urination * Severe or persistent diarrhea with unexplained weight loss * Symptoms of an allergic reaction --- ## PRECAUTIONS & WARNINGS ### Pregnancy **Olmesartan should not be used during pregnancy.** Medicines that act on the renin-angiotensin system can cause serious fetal injury or death, particularly during later pregnancy. If pregnancy occurs while taking this medicine, contact your healthcare professional promptly. ### Kidney Disease Tell your healthcare professional if you have kidney disease. Olmesartan can affect kidney function, particularly in people who are dehydrated or have conditions affecting blood flow to the kidneys. ### High Potassium Olmesartan may increase blood potassium levels. Tell your healthcare professional if you use: * Potassium supplements * Potassium-containing salt substitutes * Potassium-sparing diuretics ### Low Blood Pressure Dizziness or light-headedness may occur, particularly when beginning treatment or when the dose is increased. Rise slowly from sitting or lying positions. ### Dehydration Severe vomiting, diarrhea, excessive sweating, or inadequate fluid intake may increase the risk of low blood pressure and kidney problems. ### Liver Disease Tell your healthcare professional if you have liver disease. Amlodipine may require additional consideration in patients with significant liver impairment. ### Heart Conditions Inform your healthcare professional if you have heart failure, coronary artery disease, or other cardiovascular conditions. --- ## DRUG INTERACTIONS Tell your healthcare professional about all prescription medicines, over-the-counter medicines, vitamins, and herbal supplements you take. ### Other Antihypertensives Combining this medicine with other blood-pressure-lowering medicines may cause excessive hypotension. ### Potassium Supplements Potassium supplements and potassium-containing salt substitutes may increase the risk of **hyperkalemia** with olmesartan. ### Potassium-Sparing Diuretics Medicines such as: * Spironolactone * Eplerenone * Amiloride * Triamterene may further increase potassium levels. ### NSAIDs NSAIDs such as **ibuprofen, naproxen, and diclofenac** may reduce the blood-pressure-lowering effect and increase the risk of kidney problems, particularly in susceptible or dehydrated patients. ### Lithium Olmesartan may increase lithium concentrations and potentially increase the risk of lithium toxicity. ### Aliskiren Combining an ARB with aliskiren is generally avoided in patients with diabetes and requires particular caution in people with kidney impairment. ### Other Medicines Always provide your healthcare professional with a complete list of your medicines before starting treatment. --- ## STORAGE INFORMATION * Store at room temperature according to the manufacturer's instructions. * Keep the medicine in its original packaging. * Protect from excessive heat, moisture, and direct sunlight. * Keep the container tightly closed. * Keep out of reach of children. * Do not use after the expiry date. --- ## PRESCRIPTION STATUS **Prescription medicine.** Amlodipine 5 mg + Olmesartan 40 mg should be used under appropriate medical supervision because dose selection may depend on blood pressure, kidney function, electrolyte levels, and other medicines being taken. --- ## GENUINE MEDICINE ASSURANCE When purchasing **Amlodipine 5 mg + Olmesartan 40 mg**, obtain the medicine from a **licensed pharmacy or authorized medicine supplier**. Before use, check: * Correct medicine name and strength * Manufacturer information * Batch/lot number * Manufacturing and expiry dates * Intact packaging and seal * Proper labeling and regulatory information Do not use products with damaged packaging, altered labels, missing batch information, or questionable authenticity. --- # FAQ – AMLODIPINE 5 MG + OLMESARTAN 40 MG ### 1. What is Amlodipine 5 mg + Olmesartan 40 mg used for? It is used primarily to **treat high blood pressure (hypertension)** when combination treatment with two antihypertensive medicines is appropriate. ### 2. How does Amlodipine + Olmesartan work? Amlodipine relaxes blood vessels by blocking calcium channels, while olmesartan blocks angiotensin II receptors. Together, they reduce blood-vessel resistance and lower blood pressure. ### 3. How often should I take Amlodipine 5 mg + Olmesartan 40 mg? It is commonly taken **once daily**, but follow the exact dosage prescribed by your healthcare professional. ### 4. Can I take it with food? Yes, this combination can generally be taken **with or without food**. ### 5. Can I stop taking it when my blood pressure becomes normal? No. A normal blood-pressure reading often means the medicine is working. Do not stop treatment without consulting your healthcare professional. ### 6. Does Amlodipine + Olmesartan cause dizziness? Dizziness can occur, particularly when treatment is started or blood pressure falls too much. If dizziness is severe or persistent, contact your healthcare professional. ### 7. Why does Amlodipine cause swollen ankles? Amlodipine can cause fluid to move into tissues around the ankles, resulting in **peripheral edema**. Tell your healthcare professional if swelling is persistent or severe. ### 8. Can I take ibuprofen with Amlodipine + Olmesartan? Regular use of NSAIDs such as ibuprofen may affect blood pressure and kidney function when combined with an ARB. Consult a healthcare professional before using NSAIDs regularly. ### 9. Can I take potassium supplements with Olmesartan? Do not take potassium supplements or potassium-containing salt substitutes unless recommended by your healthcare professional because olmesartan may increase potassium levels. ### 10. Can this medicine affect kidney function? Yes. Olmesartan can affect kidney function in some patients. Kidney function may need monitoring, particularly in people with existing kidney disease or dehydration. ### 11. Is Amlodipine + Olmesartan safe during pregnancy? **Olmesartan should not be used during pregnancy.** Contact your healthcare professional immediately if you become pregnant while taking this medicine. ### 12. Can I take Amlodipine + Olmesartan while breastfeeding? Discuss breastfeeding with your healthcare professional before using this medicine. Your healthcare professional can assess whether an alternative treatment is more appropriate. ### 13. Does this medicine cure high blood pressure? It **controls high blood pressure** but does not generally cure the underlying condition. Long-term treatment and lifestyle measures may be necessary. ### 14. How long does it take to lower blood pressure? Blood pressure can begin responding after treatment starts, while the full therapeutic effect may take longer. Your healthcare professional may adjust treatment based on your readings. ### 15. What if I forget a dose? Take it when you remember unless it is almost time for your next dose. **Do not double the dose.** ### 16. Can I take other blood-pressure medicines with it? Additional blood-pressure medicines may sometimes be prescribed, but combining medicines without medical supervision can cause excessively low blood pressure. ### 17. Can Amlodipine + Olmesartan cause weight gain? Significant weight gain is not a typical direct effect. However, amlodipine-related fluid retention can sometimes cause a temporary increase in body weight. ### 18. What should I do if my blood pressure remains high? Do not increase your dose yourself. Continue taking the medicine as prescribed and discuss your blood-pressure readings with your healthcare professional. ### 19. Is Amlodipine 5 mg + Olmesartan 40 mg prescription-only? Yes, it is generally a **prescription medicine**, although exact regulatory requirements can vary by country. ### 20. What are warning signs requiring urgent medical attention? Seek urgent medical care for **fainting, severe dizziness, difficulty breathing, swelling of the face or throat, markedly reduced urination, or other severe or rapidly worsening symptoms**. --- ## MEDICAL DISCLAIMER This information about **Amlodipine 5 mg + Olmesartan 40 mg** is provided for general educational purposes only and does not replace professional medical advice, diagnosis, or treatment. This medicine should be taken only as directed by a qualified healthcare professional. Blood pressure, kidney function, potassium levels, other medicines, and individual medical conditions may affect treatment decisions. **Olmesartan should not be used during pregnancy** because medicines acting on the renin-angiotensin system can cause serious fetal harm. Do not stop or change antihypertensive treatment without medical advice. Seek prompt medical attention for severe dizziness or fainting, facial or throat swelling, difficulty breathing, markedly reduced urination, or other serious symptoms.