OLMAT-40 H

# Hydrochlorothiazide 12.5 mg + Olmesartan 40 mg ## Short Description **Hydrochlorothiazide 12.5 mg + Olmesartan 40 mg** is a combination prescription medicine used primarily to treat **high blood pressure (hypertension)**. It combines an angiotensin II receptor blocker (ARB), **olmesartan**, with a thiazide diuretic, **hydrochlorothiazide**. Olmesartan relaxes blood vessels by blocking the effects of angiotensin II, while hydrochlorothiazide helps the kidneys remove excess sodium and water. Together, they provide complementary blood-pressure-lowering effects. --- ## Key Benefits * Helps lower and control **high blood pressure**. * Combines two complementary antihypertensive mechanisms in one medicine. * **Olmesartan** relaxes blood vessels and reduces vascular resistance. * **Hydrochlorothiazide** promotes removal of excess sodium and water. * May provide better blood-pressure control when one medicine alone is insufficient. * Helps reduce the long-term risk associated with uncontrolled hypertension, such as cardiovascular and kidney complications. --- ## Uses / Indications ### 1. Hypertension The primary use of this combination is the treatment of **high blood pressure** in adults. It may be prescribed when: * Blood pressure is not adequately controlled with olmesartan alone. * Combination treatment is considered appropriate from the beginning. * A patient requires more than one antihypertensive mechanism to achieve blood-pressure targets. ### 2. Cardiovascular Risk Reduction By controlling blood pressure over time, appropriate antihypertensive treatment can help reduce the risk of complications such as: * Stroke * Heart attack * Heart failure * Kidney damage > This medicine controls blood pressure; it does not permanently cure hypertension. --- ## How It Works This medicine contains two active ingredients with different mechanisms. ### Olmesartan 40 mg Olmesartan is an **angiotensin II receptor blocker (ARB)**. It blocks the **AT1 receptor**, preventing angiotensin II from causing blood-vessel constriction and promoting sodium retention. This results in: * Relaxation of blood vessels * Reduced vascular resistance * Lower blood pressure ### Hydrochlorothiazide 12.5 mg Hydrochlorothiazide is a **thiazide diuretic**. It increases the excretion of sodium and water through the kidneys. This reduces fluid volume and contributes to lower blood pressure. ### Simple Mechanism **Olmesartan → blocks angiotensin II → relaxes blood vessels** **Hydrochlorothiazide → increases sodium and water excretion → reduces fluid volume** **Together → lower and control blood pressure.** --- ## Dosage & Administration > **Use this medicine exactly as prescribed. The appropriate dose depends on your blood pressure, kidney function, other medicines and response to treatment.** ### Usual Adult Dose For adults requiring combination therapy, a commonly used regimen is **olmesartan 40 mg + hydrochlorothiazide 12.5 mg once daily**. The dosage may be adjusted by the healthcare professional depending on blood-pressure response. ### How to Take * Take once daily at approximately the same time each day. * Swallow the tablet with water. * It may generally be taken **with or without food**. * Because hydrochlorothiazide increases urination, taking it earlier in the day may be more convenient. * Do not change the dose without medical advice. ### Missed Dose Take the missed dose when remembered unless it is nearly time for the next dose. **Do not take two doses at the same time.** --- ## Side Effects ### Common Side Effects Possible side effects include: * Dizziness * Headache * Fatigue * Increased urination * Low blood pressure * Mild gastrointestinal discomfort Hydrochlorothiazide may cause changes in blood electrolytes. ### Possible Laboratory Changes Treatment may affect: * Sodium levels * Potassium levels * Calcium levels * Uric acid levels * Blood glucose * Kidney function ### Serious Side Effects Seek medical attention for: * Severe dizziness or fainting * Significant dehydration * Severe muscle weakness or abnormal heartbeat * Severe or persistent diarrhea * Markedly reduced urine output * Facial, lip or tongue swelling * Difficulty breathing * Severe skin reactions --- ## Precautions & Warnings ### Low Blood Pressure Excessive blood-pressure reduction can cause dizziness or fainting, particularly when treatment is initiated or increased. ### Dehydration Vomiting, diarrhea, excessive sweating or inadequate fluid intake can increase the risk of dehydration and low blood pressure. ### Kidney Disease Kidney function should be assessed before and during treatment when appropriate. Significant kidney impairment may require alternative treatment or careful monitoring. ### Potassium Abnormalities Hydrochlorothiazide can lower potassium, while olmesartan can sometimes increase potassium. Blood potassium should be monitored when clinically appropriate. ### Liver Disease Tell your healthcare professional if you have liver disease. ### Diabetes Hydrochlorothiazide may affect blood glucose levels. People with diabetes may require closer monitoring. ### Gout Hydrochlorothiazide can increase uric acid levels and may trigger or worsen **gout** in susceptible individuals. ### Increased Calcium Thiazide diuretics can increase blood calcium levels. Tell your doctor if you have a history of hypercalcemia or conditions affecting calcium metabolism. ### Angioedema Olmesartan can rarely cause **angioedema**, characterized by swelling of the face, lips, tongue or throat. Seek emergency medical attention if breathing or swallowing becomes difficult. ### Pregnancy **Olmesartan should not be used during pregnancy.** Medicines that act directly on the renin-angiotensin system can cause fetal injury, particularly during the second and third trimesters. If pregnancy occurs while taking this medicine, contact your healthcare professional promptly. ### Breastfeeding Discuss use with your healthcare professional if breastfeeding. An alternative medicine may be considered depending on the clinical situation. ### Surgery Tell your doctor or anesthetist that you take this medicine before surgery because it may contribute to low blood pressure during anesthesia. --- ## Drug Interactions ### Other Blood-Pressure Medicines Combining this medicine with other antihypertensives may cause excessive lowering of blood pressure. ### Potassium Supplements Potassium supplements can increase potassium levels, particularly because olmesartan can raise serum potassium. ### Potassium-Sparing Diuretics Medicines such as **spironolactone, amiloride or triamterene** may increase the risk of hyperkalemia when combined with olmesartan. ### NSAIDs Medicines such as: * Ibuprofen * Naproxen * Diclofenac may reduce the blood-pressure-lowering effect and can increase the risk of kidney problems, particularly in dehydrated patients or those with impaired kidney function. ### Lithium Olmesartan and hydrochlorothiazide may increase **lithium concentrations**, potentially increasing the risk of lithium toxicity. This combination generally requires careful medical supervision. ### Diabetes Medicines Hydrochlorothiazide can affect blood glucose control and may alter the response to certain antidiabetic medicines. ### Corticosteroids Systemic corticosteroids may increase the risk of potassium loss when used with hydrochlorothiazide. ### Cholestyramine/Colestipol These medicines can reduce absorption of hydrochlorothiazide. Your healthcare professional may recommend separating administration times. ### Alcohol Alcohol may increase the blood-pressure-lowering effect and dizziness. > Tell your doctor or pharmacist about **all prescription medicines, OTC medicines, vitamins and herbal supplements** you take. --- ## Storage Information * Store according to the manufacturer's instructions. * Keep at the recommended room temperature. * Protect from excessive heat, moisture and direct sunlight. * Keep tablets in their original packaging. * Keep the container tightly closed where applicable. * Keep out of reach of children. * Do not use after the expiry date. --- ## Prescription Status **Hydrochlorothiazide 12.5 mg + Olmesartan 40 mg is generally a prescription medicine.** Because it can affect blood pressure, kidney function and electrolyte levels, treatment should be supervised by a qualified healthcare professional. --- ## Genuine Medicine Assurance When purchasing **Hydrochlorothiazide 12.5 mg + Olmesartan 40 mg**: * Purchase from a **licensed and reputable pharmacy**. * Verify the exact medicine name and strengths. * Check the manufacturer's name. * Verify the batch/lot number and expiry date. * Ensure the blister pack and outer packaging are intact. * Check product registration information where applicable. * Do not use tablets from damaged, opened or suspicious packaging. * Avoid purchasing prescription medicines from unauthorized sellers. * Follow the manufacturer's storage instructions. * If you suspect a counterfeit medicine, contact the manufacturer, licensed pharmacy or relevant medicines regulatory authority. --- # Frequently Asked Questions (FAQ) ### 1. What is Hydrochlorothiazide 12.5 mg + Olmesartan 40 mg used for? It is primarily used to **treat high blood pressure (hypertension)** in adults who require combination therapy. ### 2. What are the ingredients in this medicine? Each tablet contains: * **Olmesartan 40 mg** * **Hydrochlorothiazide 12.5 mg** ### 3. How does Olmesartan lower blood pressure? Olmesartan blocks angiotensin II at the AT1 receptor, preventing blood-vessel constriction and helping blood vessels remain relaxed. ### 4. How does Hydrochlorothiazide lower blood pressure? Hydrochlorothiazide increases the excretion of sodium and water through the kidneys, reducing fluid volume and helping lower blood pressure. ### 5. Can I take this medicine once daily? Yes. The **40 mg/12.5 mg combination is commonly taken once daily**, but follow the dose prescribed specifically for you. ### 6. Should I take this medicine in the morning or at night? Because hydrochlorothiazide increases urination, taking it earlier in the day is often more convenient. Follow your doctor's instructions if a different schedule has been prescribed. ### 7. Can this medicine cure high blood pressure? No. It helps **control blood pressure**. Long-term treatment, along with appropriate lifestyle measures, may be necessary. ### 8. Can Hydrochlorothiazide + Olmesartan cause dizziness? Yes. Dizziness can occur because both medicines lower blood pressure. Stand up slowly, especially when beginning treatment. ### 9. Does Hydrochlorothiazide make you urinate more? Yes. Hydrochlorothiazide is a diuretic and can increase urine production, particularly after taking a dose. ### 10. Can I take this medicine with ibuprofen? Regular or high-dose NSAID use, including ibuprofen, may reduce its blood-pressure-lowering effect and increase the risk of kidney problems. Consult your healthcare professional before using NSAIDs regularly. ### 11. Can I take potassium supplements with Olmesartan? Do not take potassium supplements or potassium-containing salt substitutes without medical advice. Olmesartan can increase potassium levels in some patients. ### 12. Can this medicine cause low potassium? Yes. Hydrochlorothiazide can lower potassium levels, although olmesartan may increase potassium. Your healthcare professional may monitor electrolytes. ### 13. Can Hydrochlorothiazide worsen gout? It can. Hydrochlorothiazide may increase uric acid levels and can trigger or worsen gout in susceptible people. ### 14. Can people with diabetes take this medicine? It may be used in some people with diabetes, but hydrochlorothiazide can affect blood glucose. Blood sugar and kidney function may need monitoring. ### 15. Can I take Olmesartan + Hydrochlorothiazide during pregnancy? **No. Olmesartan should not be used during pregnancy.** Contact your healthcare professional promptly if you become pregnant while taking this medicine. ### 16. Can I use this medicine while breastfeeding? Discuss this with your healthcare professional. Depending on the situation, another blood-pressure medicine may be preferred. ### 17. What should I do if I miss a dose? Take it when remembered unless it is nearly time for the next dose. **Do not double the next dose.** ### 18. Can I stop this medicine when my blood pressure becomes normal? Do not stop treatment without medical advice. Normal blood pressure may indicate that the medicine is working effectively. ### 19. What monitoring may be required while taking this medicine? Your healthcare professional may monitor: * Blood pressure * Kidney function * Sodium * Potassium * Uric acid * Blood glucose when appropriate ### 20. Is Hydrochlorothiazide 12.5 mg + Olmesartan 40 mg available without a prescription? It is generally a **prescription-only medicine**, although specific regulations can vary by country. --- ## Medical Disclaimer This information about **Hydrochlorothiazide 12.5 mg + Olmesartan 40 mg** is provided for educational and general informational purposes only. It is **not a substitute for professional medical advice, diagnosis or treatment**. This combination is used primarily to control hypertension. Treatment should be individualized according to blood pressure, kidney function, electrolyte levels, other medicines and underlying medical conditions. **Olmesartan should not be used during pregnancy** because medicines acting on the renin-angiotensin system can cause serious fetal harm. Patients with kidney disease, dehydration, electrolyte abnormalities, gout, diabetes or liver disease should inform their healthcare professional before treatment. Do not start, stop or change the dose without medical advice. Seek urgent medical attention for **facial or throat swelling, difficulty breathing, severe fainting, severe dehydration or other serious symptoms**.