PRESIN-H

# Hydrochlorothiazide 12.5 mg + Amlodipine 5 mg ## Short Description **Hydrochlorothiazide 12.5 mg + Amlodipine 5 mg** is a combination prescription medicine used for the management of **high blood pressure (hypertension)**. It combines two antihypertensive agents that work through different mechanisms to help relax blood vessels, remove excess fluid, and improve blood pressure control. This combination may be prescribed when a single blood pressure medicine is not sufficient to achieve target blood pressure levels. --- # Key Benefits Section - Helps lower high blood pressure. - Provides dual-action blood pressure control. - Helps relax and widen blood vessels. - Helps reduce excess fluid retention. - Reduces workload on the heart. - Supports cardiovascular health. - Helps reduce the risk of complications related to uncontrolled hypertension. - May improve long-term blood pressure management. --- # Uses / Indications Hydrochlorothiazide + Amlodipine may be prescribed for: ## Hypertension (High Blood Pressure) - Treatment of mild to severe hypertension. - Blood pressure control in patients requiring combination therapy. ## Cardiovascular Risk Reduction Maintaining controlled blood pressure may help reduce the risk of: - Stroke. - Heart attack. - Heart-related complications. - Kidney damage caused by uncontrolled hypertension. --- # How It Works This medicine contains two active ingredients: ## Hydrochlorothiazide - A thiazide diuretic ("water pill"). - Increases removal of excess salt and water through urine. - Helps reduce blood volume. - Lowers pressure on blood vessel walls. ## Amlodipine - A calcium channel blocker. - Prevents calcium from entering blood vessel muscle cells. - Causes relaxation and widening of blood vessels. - Improves blood flow and lowers blood pressure. Together, they provide complementary effects for better blood pressure control. --- # Dosage & Administration Take **Hydrochlorothiazide 12.5 mg + Amlodipine 5 mg** exactly as prescribed by your doctor. ## General Instructions - Usually taken once daily. - May be taken with or without food. - Take at the same time each day. - Swallow with water. ## Dose Adjustment Your doctor may adjust the dose depending on: - Blood pressure response. - Kidney function. - Age. - Other medicines being used. ## Missed Dose - Take the missed dose when remembered. - If it is close to your next dose, skip it. - Do not take two doses together. --- # Side Effects ## Common Side Effects - Dizziness. - Headache. - Fatigue. - Increased urination. - Swelling of ankles or feet. - Flushing. - Nausea. - Mild stomach discomfort. ## Hydrochlorothiazide-Related Effects - Increased thirst. - Electrolyte imbalance. - Increased uric acid levels. ## Amlodipine-Related Effects - Ankle swelling (edema). - Palpitations. - Warm sensation or flushing. ## Serious Side Effects (Seek Medical Help) - Severe allergic reaction. - Fainting. - Severe dehydration. - Irregular heartbeat. - Severe muscle weakness. --- # Precautions & Warnings Before taking this medicine, inform your doctor if you have: - Kidney disease. - Liver disease. - Heart problems. - Low blood pressure. - Electrolyte imbalance. - Diabetes. - Gout. - Allergy to sulfonamide medicines. ## Important Warnings - Monitor blood pressure regularly. - Avoid dehydration, especially during hot weather or illness. - Rise slowly from sitting or lying positions to reduce dizziness. - Inform your doctor before surgery. - Do not stop medicine suddenly without medical advice. - Regular monitoring of kidney function and electrolytes may be required. --- # Drug Interactions Hydrochlorothiazide + Amlodipine may interact with: ## Other Blood Pressure Medicines - ACE inhibitors. - ARBs. - Beta-blockers. - Other calcium channel blockers. May increase blood pressure-lowering effects. ## NSAIDs (Pain Relievers) Examples: - Ibuprofen. - Naproxen. May reduce effectiveness and affect kidney function. ## Diuretics Other water pills may increase dehydration or electrolyte imbalance. ## Lithium Hydrochlorothiazide may increase lithium levels and toxicity risk. ## Corticosteroids May increase the risk of electrolyte disturbances. ## Diabetes Medicines May affect blood glucose control. Always inform your doctor about all prescription medicines, supplements, and herbal products you use. --- # Storage Information - Store below **25°C**. - Keep in a cool and dry place. - Protect from moisture and direct sunlight. - Keep tablets in the original packaging. - Keep away from children. - Do not use after the expiry date. --- # Prescription Status **Prescription Only Medicine (Rx)** Hydrochlorothiazide 12.5 mg + Amlodipine 5 mg should be used under medical supervision with regular monitoring of blood pressure and overall health status. --- # Genuine Medicine Assurance We provide **100% genuine, quality-assured medicines** sourced from licensed pharmaceutical manufacturers and authorized distributors. All medicines are stored and handled according to recommended pharmaceutical standards to maintain their safety, quality, and effectiveness. --- # FAQ Section (Frequently Asked Questions) ## 1. What is Hydrochlorothiazide 12.5 mg + Amlodipine 5 mg used for? It is used to treat high blood pressure by combining a diuretic and a calcium channel blocker. --- ## 2. How does this combination lower blood pressure? Hydrochlorothiazide removes excess salt and water, while Amlodipine relaxes blood vessels to improve blood flow. --- ## 3. Can I take this medicine every day? Yes, it is usually taken daily as prescribed by your doctor. --- ## 4. Does Hydrochlorothiazide cause frequent urination? Yes. Since it is a diuretic, increased urination may occur, especially after taking the dose. --- ## 5. Does Amlodipine cause swelling? Yes. Some people may experience swelling of ankles or feet. --- ## 6. Can I stop this medicine if my blood pressure becomes normal? No. Blood pressure may rise again if treatment is stopped. Consult your doctor before making changes. --- ## 7. Can this medicine be taken at night? It may be taken at different times depending on your doctor's advice. Diuretics are often preferred earlier in the day due to increased urination. --- ## 8. Can I take this medicine with food? Yes. It can generally be taken with or without food. --- ## 9. Is this medicine safe during pregnancy? Consult your doctor before use during pregnancy or breastfeeding. --- ## 10. What should I avoid while taking this medicine? Avoid excessive alcohol intake and dehydration. Do not take potassium supplements unless advised. --- ## 11. How long does this medicine take to work? Blood pressure improvement may begin within days, but full effects may take several weeks. --- ## 12. What monitoring is needed during treatment? Your doctor may monitor blood pressure, kidney function, and electrolyte levels. --- # Medical Disclaimer The information provided on this page is for **educational and informational purposes only** and does not replace professional medical advice, diagnosis, or treatment. **Hydrochlorothiazide 12.5 mg + Amlodipine 5 mg** is a prescription medicine and should only be used under the guidance of a qualified healthcare professional. Always consult your doctor before starting, stopping, or changing any medication. ```