REVAS AM 50MG TAB

# Amlodipine 5 mg + Losartan 50 mg ## SHORT DESCRIPTION Amlodipine 5 mg + Losartan 50 mg is a **combination antihypertensive medicine** used primarily to treat high blood pressure (hypertension). It combines a calcium channel blocker, amlodipine, with an angiotensin II receptor blocker (ARB), losartan. The two medicines lower blood pressure through different mechanisms, providing complementary blood-pressure control and helping reduce the workload on the heart. ## KEY BENEFITS * Helps lower high blood pressure * Combines two complementary blood-pressure-lowering medicines * Helps relax and widen blood vessels * Reduces the workload on the heart * May help reduce the risk of cardiovascular complications associated with uncontrolled hypertension * Losartan may provide kidney-protective benefits in certain patients, particularly those with diabetes and hypertension * Convenient once-daily combination therapy for many patients ## USES / INDICATIONS Amlodipine 5 mg + Losartan 50 mg may be prescribed for: * **Hypertension (high blood pressure)** * Patients whose blood pressure is not adequately controlled with one medicine alone * Patients who require combination antihypertensive therapy * Cardiovascular risk reduction through effective blood-pressure control The exact treatment plan should be determined by a healthcare professional based on blood pressure, medical history and other medicines being taken. ## HOW IT WORKS ### Amlodipine Amlodipine is a **calcium channel blocker (CCB)**. It reduces the movement of calcium into the muscle cells of blood vessel walls. This causes the blood vessels to relax and widen, helping blood flow more easily and lowering blood pressure. ### Losartan Losartan is an **angiotensin II receptor blocker (ARB)**. It blocks the action of angiotensin II, a hormone that normally causes blood vessels to narrow and promotes sodium and water retention. By blocking angiotensin II, losartan helps blood vessels relax and lowers blood pressure. ### Combination Effect Amlodipine and losartan lower blood pressure through different pathways, which can provide more effective blood-pressure control than either medicine alone in appropriate patients. ## DOSAGE & ADMINISTRATION * The usual dose of this fixed-dose combination is **one tablet once daily**, containing amlodipine 5 mg and losartan 50 mg, when prescribed at this strength. * Take the tablet at approximately the same time each day. * It may generally be taken with or without food. * Swallow the tablet whole with water. * Take it regularly even if you feel well, because hypertension often does not cause noticeable symptoms. * Your doctor may adjust the dose according to your blood pressure and response to treatment. * Continue recommended dietary changes, exercise and other lifestyle measures alongside the medicine. ### Missed Dose If you miss a dose, take it when you remember unless it is almost time for the next dose. Do not take two doses together to make up for a missed dose. ## SIDE EFFECTS Possible side effects include: * Dizziness * Headache * Ankle or leg swelling * Flushing * Fatigue * Palpitations * Low blood pressure * Increased blood potassium levels * Nausea * Muscle cramps ### Serious Side Effects Rare but serious reactions may include: * Severe allergic reaction * Significant fall in blood pressure * Kidney function changes * High potassium levels * Angioedema, which may cause swelling of the face, lips, tongue or throat Seek immediate medical attention if you develop severe swelling of the face or throat, difficulty breathing, fainting or severe weakness. ## PRECAUTIONS & WARNINGS * Do not use this medicine if you have a serious allergy to amlodipine, losartan or any component of the formulation. * **Losartan should not be used during pregnancy**, particularly after the first trimester, because medicines that act on the renin-angiotensin system can cause serious fetal harm. * Inform your doctor immediately if you become pregnant while taking this medicine. * Tell your doctor if you have kidney disease or reduced kidney function. * Inform your doctor if you have liver disease. * Your doctor may monitor kidney function and blood potassium levels during treatment. * Avoid potassium supplements or potassium-containing salt substitutes unless specifically recommended. * Tell your doctor if you experience persistent dizziness or fainting. * Inform your doctor if you have heart disease or significant narrowing of the aortic valve. * Amlodipine may cause ankle swelling, particularly during the initial stages of treatment. * Do not stop antihypertensive treatment without consulting your doctor. ## DRUG INTERACTIONS Amlodipine + losartan may interact with: * **Potassium supplements and potassium-containing salt substitutes** — may increase blood potassium. * **Potassium-sparing diuretics** such as spironolactone — may increase the risk of hyperkalemia. * **NSAIDs** such as ibuprofen and naproxen — may reduce the blood-pressure-lowering effect and increase the risk of kidney problems. * **Other antihypertensive medicines** — may increase the blood-pressure-lowering effect. * **Diuretics** — may increase the risk of excessive blood-pressure reduction. * **Lithium** — losartan may increase lithium concentrations and toxicity risk. * **Certain CYP3A4 inhibitors** — may increase amlodipine concentrations. * **Rifampicin and other enzyme inducers** — may reduce amlodipine exposure. * **Aliskiren** — combination with losartan may increase the risk of low blood pressure, high potassium and kidney impairment in certain patients. Tell your doctor or pharmacist about all prescription medicines, over-the-counter medicines, vitamins and herbal supplements you use. ## STORAGE INFORMATION * Store according to the manufacturer's instructions. * Keep the tablets in their original packaging. * Protect from excessive heat and moisture. * Keep away from direct sunlight. * Keep out of reach of children. * Do not use after the expiry date. * Do not use tablets if the packaging is damaged or the medicine appears abnormal. ## PRESCRIPTION STATUS **Prescription medicine.** Amlodipine 5 mg + Losartan 50 mg should be used under the supervision of a qualified healthcare professional. Prescription requirements may vary according to local regulations. ## GENUINE MEDICINE ASSURANCE For safe and genuine medicine use: * Purchase the medicine only from a licensed and reputable pharmacy. * Check the medicine name, strength, batch number and expiry date. * Ensure the packaging and seal are intact. * Avoid medicines with damaged, altered or suspicious packaging. * Purchase medicines only from authorized sources. * Do not share your prescription medicine with others. * Consult a pharmacist if you have concerns about product authenticity. ## FAQ ### What is Amlodipine 5 mg + Losartan 50 mg used for? It is primarily used to **treat high blood pressure (hypertension)**. The combination may be prescribed when one blood-pressure medicine alone does not provide adequate control. ### Is Amlodipine + Losartan a blood pressure medicine? Yes. Both amlodipine and losartan lower blood pressure, but they work through different mechanisms. ### How does Amlodipine 5 mg work? Amlodipine relaxes and widens blood vessels by blocking calcium entry into vascular smooth muscle cells. This reduces resistance to blood flow and lowers blood pressure. ### How does Losartan 50 mg work? Losartan blocks the effects of angiotensin II, a hormone that narrows blood vessels. This helps blood vessels relax and lowers blood pressure. ### Can Amlodipine + Losartan be taken once daily? Yes. This combination is commonly administered once daily when prescribed at this strength. Follow the exact instructions provided by your doctor. ### Can Amlodipine + Losartan be taken with food? Yes. The combination can generally be taken with or without food. Taking it at the same time each day can help maintain consistent treatment. ### Does Amlodipine + Losartan cause dizziness? Dizziness can occur, particularly when treatment is started or the blood pressure falls too much. Rise slowly from sitting or lying down and inform your doctor if dizziness is severe or persistent. ### Does Amlodipine cause ankle swelling? Yes. **Ankle or leg swelling (edema)** is a known side effect of amlodipine. Inform your doctor if swelling is persistent or severe. ### Can Amlodipine + Losartan lower blood pressure too much? Yes. Excessive blood-pressure reduction can cause dizziness, weakness or fainting. Your doctor may adjust the dose if this occurs. ### Can I take Amlodipine + Losartan with other blood pressure medicines? It may be combined with other medicines when medically appropriate, but taking multiple blood-pressure medicines can increase the risk of hypotension. Always tell your doctor about all medicines you take. ### Can I take potassium supplements with Losartan? Do not take potassium supplements or potassium-containing salt substitutes unless your doctor recommends them. Losartan can increase potassium levels in the blood. ### Can I take ibuprofen with Amlodipine + Losartan? NSAIDs such as ibuprofen can interact with losartan and may reduce its blood-pressure-lowering effect or increase the risk of kidney problems. Consult your doctor or pharmacist before using NSAIDs regularly. ### Can Amlodipine + Losartan affect the kidneys? Losartan can affect kidney function in some patients. It may also provide kidney benefits in certain patients with hypertension and diabetes. Kidney function and potassium may be monitored during treatment. ### Can I take Amlodipine + Losartan during pregnancy? No. Losartan can cause serious harm to an unborn baby and should not be used during pregnancy. Contact your doctor immediately if you become pregnant while taking this medicine. ### Can I stop Amlodipine + Losartan when my blood pressure becomes normal? Do not stop the medicine without medical advice. Normal blood pressure may indicate that the treatment is working. Stopping treatment can cause blood pressure to rise again. ### What should I do if I miss a dose? Take the missed dose when you remember unless it is nearly time for your next dose. Do not take two tablets together to compensate for a missed dose. ### How long does Amlodipine + Losartan take to lower blood pressure? Both medicines begin lowering blood pressure after administration, but the full treatment effect may take longer to become established. Regular daily use is important for maintaining blood-pressure control. ### Does Amlodipine + Losartan cure high blood pressure? No. It controls blood pressure but does not permanently cure hypertension. Long-term treatment, along with healthy lifestyle measures, may be necessary. ## MEDICAL DISCLAIMER This information is provided for educational and informational purposes only and should not replace professional medical advice, diagnosis or treatment. Amlodipine 5 mg + Losartan 50 mg should be taken only as prescribed by a qualified healthcare professional. The appropriate dose depends on blood pressure, kidney and liver function, medical history and other medicines being used. Do not start, stop or change your antihypertensive treatment without consulting your doctor or pharmacist.