SCARIN

# Permethrin 5% ## SHORT DESCRIPTION Permethrin 5% is a **topical antiparasitic medicine** primarily used to treat **scabies**, a skin infestation caused by the mite *Sarcoptes scabiei*. It works by disrupting the nervous system of mites, causing their paralysis and death. Permethrin 5% cream is generally applied to the skin according to specific instructions and may be used for adults and children when medically appropriate. ## KEY BENEFITS * Effectively treats scabies when used correctly * Helps eliminate scabies mites * Helps reduce the spread of scabies to close contacts when treatment instructions are followed * Can help relieve itching associated with scabies as the infestation clears * Suitable for use in many adults and children when used according to age-specific instructions * Topical treatment with limited systemic absorption when used as directed ## USES / INDICATIONS Permethrin 5% is primarily indicated for: * **Scabies** * Infestation caused by *Sarcoptes scabiei* mites It may also be used in specific circumstances according to medical advice, but **Permethrin 5% should not be assumed to be appropriate for every type of skin rash or itching**. ## HOW IT WORKS Permethrin belongs to a group of medicines called **pyrethroids**. It acts on the nervous system of mites and other susceptible parasites by interfering with sodium channels in their nerve cells. This causes paralysis and ultimately kills the mites. Permethrin is toxic to mites but has relatively low toxicity to humans when used appropriately. ## DOSAGE & ADMINISTRATION * Use Permethrin 5% exactly as directed by your doctor or according to the product instructions. * For typical scabies treatment, the cream is generally applied as a thin layer to the **entire body from the neck downward** in adults, although application instructions can differ by age and product. * In infants and young children, the scalp, neck, or other areas may also need treatment according to medical advice. * Pay particular attention to areas such as: * Between the fingers and toes * Wrists * Elbows * Armpits * Waist * Buttocks * Genital area * Under the fingernails * Leave the cream on for the period specified in the product instructions, commonly **8–14 hours**, then wash it off. * If hands are washed during the treatment period, reapply the cream to the hands. * Put on clean clothing after treatment. * Wash bedding, clothing, and towels used recently according to appropriate scabies-control instructions. * A second application may sometimes be recommended about **7 days later**, depending on the product and clinical response. * Follow your healthcare professional's instructions regarding treatment of household or close contacts. ### Important Itching can continue for **several weeks after successful treatment** because the skin can remain sensitive to mite particles. Persistent itching does not always mean that treatment has failed. ## SIDE EFFECTS ### Common Side Effects * Mild burning or stinging * Itching * Redness * Tingling * Temporary skin irritation * Dryness * Mild rash These effects may occur after application and are often temporary. ### Serious Side Effects Seek medical attention if you develop: * Severe skin irritation * Significant swelling * Blistering * Severe allergic reaction * Difficulty breathing * Swelling of the face, lips, tongue, or throat ## PRECAUTIONS & WARNINGS * **For external use only.** * Avoid contact with the eyes. * Avoid contact with the inside of the nose and mouth. * Do not swallow the cream. * Wash the product off immediately if it accidentally enters the eyes. * Use caution when applying to severely irritated or damaged skin. * Infants and young children should be treated according to age-specific medical advice. * Do not apply more frequently or use larger amounts than recommended. * Keep away from children. * Wash hands after application unless the hands themselves are part of the treatment area. * Treating close household contacts may be necessary to prevent reinfestation. * Clean recently used bedding, clothing, and towels appropriately. * Do not repeatedly apply permethrin simply because itching continues; post-scabies itching can persist after the mites have been eliminated. ### Pregnancy and Breastfeeding Inform your healthcare professional if you are pregnant, planning pregnancy, or breastfeeding. Permethrin is generally considered a preferred topical treatment for scabies when treatment is medically necessary, but it should still be used according to professional advice. ## DRUG INTERACTIONS Permethrin 5% has **minimal systemic absorption**, so significant drug interactions are uncommon when it is used correctly. However: * Avoid applying other topical medicines to the same area unless advised by a healthcare professional. * Tell your doctor or pharmacist about other creams, lotions, ointments, or medicated skin products you are using. * Do not combine multiple antiparasitic treatments without medical advice. ## STORAGE INFORMATION * Store Permethrin 5% according to the manufacturer's instructions. * Keep the tube tightly closed when not in use. * Store at room temperature unless otherwise specified on the product label. * Protect from excessive heat and direct sunlight. * Keep away from moisture. * Keep out of the sight and reach of children. * Do not use after the expiry date. * Do not use the cream if the packaging is damaged or the product has changed significantly in appearance or texture. ## PRESCRIPTION STATUS **Prescription Status May Vary** Permethrin 5% may be available with or without a prescription depending on the country, formulation, and local regulations. For suspected scabies, appropriate diagnosis and treatment guidance from a healthcare professional is recommended. ## GENUINE MEDICINE ASSURANCE When purchasing Permethrin 5%: * Purchase from a licensed and reputable pharmacy. * Check that the packaging is sealed and intact. * Verify the medicine name and concentration. * Check the batch number and expiry date. * Ensure the cream has been stored appropriately. * Avoid products with damaged, altered, or suspicious packaging. * Purchase from an authorized pharmaceutical supplier. * Consult a pharmacist if you have concerns about authenticity or product quality. ## FAQ — FREQUENTLY ASKED QUESTIONS ### What is Permethrin 5% used for? Permethrin 5% cream is primarily used to treat **scabies**, a skin infestation caused by microscopic mites. ### Does Permethrin 5% kill scabies mites? Yes. Permethrin interferes with the nervous system of scabies mites and kills them when applied correctly. ### How do I use Permethrin 5% for scabies? For typical adult treatment, the cream is applied to the skin from the neck downward, including areas where mites commonly hide. It is usually left on for the recommended period and then washed off. Follow your specific product instructions or doctor's directions. ### How long should Permethrin 5% stay on the skin? Many permethrin 5% products are left on the skin for approximately **8–14 hours**, but you should follow the instructions provided with your particular product. ### Can Permethrin 5% be used on the face? The face and scalp are not routinely treated in adults unless specifically directed. Infants and young children may require treatment of additional areas. Follow age-specific instructions from your healthcare professional. ### Can Permethrin 5% be used for children? Yes, permethrin 5% may be used in children when appropriate. The areas treated and application instructions can differ by age, so follow pediatric guidance carefully. ### Does Permethrin 5% stop itching immediately? Not necessarily. Scabies-related itching can continue for **several weeks after successful treatment** because the skin may remain irritated even after the mites have been eliminated. ### Why am I still itching after using Permethrin 5%? Persistent itching does not always mean treatment failure. It can be caused by an ongoing allergic or inflammatory reaction to mite particles. However, new burrows or new mite-like lesions may indicate reinfestation or treatment failure and should be evaluated. ### Do I need to repeat Permethrin 5% treatment? A second application may be recommended approximately 7 days after the first treatment in some cases. Follow your doctor's instructions or the specific product label. ### Should my family members use Permethrin 5%? People who have had close skin-to-skin contact with someone who has scabies may need treatment at the same time, even if they do not yet have symptoms. A healthcare professional can advise which contacts require treatment. ### Should I wash my clothes and bedding after using Permethrin? Yes. Recently used clothing, bedding, and towels should be appropriately washed and dried according to scabies-control recommendations to help reduce the risk of reinfestation. ### Can Permethrin 5% be used for lice? Permethrin products are available in different concentrations and formulations for different parasites. **Permethrin 5% cream is primarily used for scabies**, and it should not automatically be substituted for a product specifically intended for head lice. ### Can Permethrin 5% be used for fungal infections? No. Permethrin is an antiparasitic medicine and does not treat fungal infections such as ringworm or candidiasis. ### Can Permethrin 5% be used during pregnancy? Permethrin is generally considered an appropriate topical treatment for scabies during pregnancy when treatment is necessary. However, pregnant patients should consult a healthcare professional before use. ### Can Permethrin 5% be used while breastfeeding? Consult your healthcare professional before use. If applying to the breast or nipple area, the product should be completely removed before breastfeeding according to professional advice. ### Is Permethrin 5% safe? When used according to the recommended instructions, permethrin 5% is generally well tolerated. Mild skin irritation, burning, or itching can occur. ### What happens if I use too much Permethrin 5%? Excessive or repeated application may increase skin irritation and potentially increase absorption. Do not use more than recommended. Seek medical advice if a large amount has been applied or if severe symptoms occur. ### Can I use other creams after Permethrin 5%? Other topical products may sometimes be needed to manage persistent itching or skin irritation, but they should be used according to medical advice. Avoid applying multiple medicated creams to the same area without guidance. ### Is Permethrin 5% available without a prescription? Prescription requirements vary by country. Some formulations may be available without a prescription, while others require medical authorization. ## MEDICAL DISCLAIMER This information is provided for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Permethrin 5% should be used according to the specific product instructions or as directed by a qualified healthcare professional. Correct treatment of scabies may require simultaneous treatment of close contacts and appropriate cleaning of recently used clothing, bedding, and towels. Persistent itching after treatment does not necessarily mean treatment failure, but new burrows or new lesions should be assessed by a healthcare professional. Do not repeatedly apply permethrin without medical advice. Seek urgent medical attention for severe skin reactions or signs of a serious allergic reaction.