TELCLOR 6.25/80

# Chlorthalidone 6.25 mg + Telmisartan 80 mg ## Short Description **Chlorthalidone 6.25 mg + Telmisartan 80 mg** is a combination blood-pressure medicine containing a **thiazide-like diuretic (chlorthalidone)** and an **angiotensin II receptor blocker (telmisartan)**. It is used primarily to treat **high blood pressure (hypertension)** when treatment with one medicine alone does not provide adequate control. The combination lowers blood pressure through two complementary mechanisms: chlorthalidone helps remove excess sodium and water, while telmisartan relaxes blood vessels by blocking the action of angiotensin II. --- ## Key Benefits * Helps **lower and control high blood pressure**. * Combines two complementary antihypertensive mechanisms. * Chlorthalidone promotes elimination of excess **sodium and water**. * Telmisartan helps relax blood vessels and reduce vascular resistance. * Once-daily administration may support treatment convenience. * Effective blood-pressure control can help reduce the long-term risk of **stroke, heart attack and other cardiovascular complications**. --- ## Uses / Indications ### Hypertension The combination is primarily used for the treatment of **essential hypertension** in adults when additional blood-pressure reduction is needed. ### Combination Therapy It may be prescribed when: * Blood pressure remains above target with telmisartan alone. * A diuretic is needed in addition to an ARB. * A healthcare professional determines that combination therapy is appropriate. > This medicine is **not intended to replace lifestyle measures** such as a heart-healthy diet, appropriate physical activity, weight management and reduced sodium intake. --- ## How It Works This medicine combines two active ingredients that lower blood pressure in different ways. ### Chlorthalidone 6.25 mg Chlorthalidone is a **thiazide-like diuretic**. It reduces sodium reabsorption in the kidneys, increasing the excretion of: * Sodium * Chloride * Water This initially reduces blood volume and, with continued treatment, contributes to lower peripheral vascular resistance. ### Telmisartan 80 mg Telmisartan is an **angiotensin II receptor blocker (ARB)**. It blocks the **AT1 receptor**, preventing angiotensin II from producing effects such as: * Blood-vessel constriction * Sodium retention * Aldosterone release This causes blood vessels to relax and helps reduce blood pressure. ### Combined Effect **Chlorthalidone → increased sodium/water excretion → reduced fluid volume** **Telmisartan → AT1 receptor blockade → blood-vessel relaxation → reduced vascular resistance** Together, these effects provide complementary blood-pressure reduction. --- ## Dosage & Administration > **Use only according to the prescription and the specific product label.** ### Usual Adult Use The combination contains **telmisartan 80 mg + chlorthalidone 6.25 mg**. The appropriate dose depends on the patient's blood pressure, kidney function, electrolyte levels and previous antihypertensive treatment. A healthcare professional may prescribe this combination as **once-daily therapy** when appropriate. ### How to Take * Take exactly as prescribed. * It may generally be taken **with or without food**. * Take it at approximately the same time each day. * Swallow the tablet with water. * Because chlorthalidone has a diuretic effect, taking it earlier in the day may be preferable for some patients to reduce nighttime urination. ### Do Not * Do not take more than the prescribed dose. * Do not stop telmisartan suddenly without medical advice. * Do not change the dose based only on home blood-pressure readings. ### Missed Dose Take the missed dose when remembered unless it is nearly time for the next scheduled dose. **Do not take two doses at once.** --- ## Side Effects ### Common Side Effects Possible side effects include: * Dizziness * Headache * Increased urination * Fatigue * Nausea * Low blood pressure * Mild gastrointestinal discomfort ### Electrolyte-Related Effects Chlorthalidone can alter blood electrolyte levels and may cause: * Low potassium * Low sodium * Low magnesium * Increased calcium levels Symptoms of significant electrolyte disturbance may include: * Muscle weakness * Muscle cramps * Unusual tiredness * Confusion * Irregular heartbeat ### Telmisartan-Related Effects Possible effects include: * Dizziness * Low blood pressure * Increased potassium levels * Changes in kidney function ### Serious Side Effects Seek urgent medical attention for: * Fainting or severe dizziness * Severe weakness * Irregular heartbeat * Swelling of the face, lips, tongue or throat * Difficulty breathing * Significant reduction in urine output --- ## Precautions & Warnings ### Kidney Function Kidney function should be assessed when appropriate, particularly in patients with: * Chronic kidney disease * Diabetes * Heart failure * Dehydration ### Potassium Levels Telmisartan can **increase potassium**, while chlorthalidone can decrease potassium. The net effect varies between individuals. Blood potassium may therefore need monitoring. ### Dehydration Excessive fluid loss from: * Vomiting * Diarrhea * Excessive sweating * Very low fluid intake can increase the risk of low blood pressure and kidney problems. ### Low Blood Pressure Dizziness or fainting can occur, especially when treatment is started or when the patient is dehydrated. ### Pregnancy **Telmisartan should not be used during pregnancy.** Medicines that act directly on the renin-angiotensin system can cause serious fetal harm, particularly during the second and third trimesters. If pregnancy occurs while taking this medicine, contact your healthcare professional promptly. ### Diabetes Chlorthalidone can affect glucose levels. Patients with diabetes may require periodic blood-glucose monitoring. ### Gout Chlorthalidone can increase uric acid levels and may trigger or worsen **gout**. ### Liver Disease Tell your healthcare professional if you have liver disease, particularly because telmisartan is extensively processed by the liver. ### Sun Sensitivity Chlorthalidone may increase sensitivity to sunlight in some patients. Use appropriate sun protection. --- ## Drug Interactions ### Potassium Supplements and Potassium-Sparing Medicines Telmisartan can increase potassium levels. Combining it with: * Potassium supplements * Potassium-containing salt substitutes * Spironolactone * Eplerenone * Amiloride * Triamterene may increase the risk of **hyperkalemia**. ### NSAIDs Medicines such as: * Ibuprofen * Naproxen * Diclofenac may reduce the blood-pressure-lowering effect and increase the risk of kidney impairment, particularly in dehydrated patients or those with kidney disease. ### Lithium Telmisartan and chlorthalidone can both increase the risk of **lithium toxicity**. Concomitant use generally requires careful monitoring or avoidance. ### Other Blood-Pressure Medicines Other antihypertensive medicines may produce an additive blood-pressure-lowering effect. ### Digoxin Electrolyte changes caused by chlorthalidone may increase the risk of cardiac effects associated with digoxin. ### Corticosteroids Long-term corticosteroid therapy can increase the risk of potassium loss when used with a diuretic. ### Alcohol Alcohol may increase dizziness or low blood pressure. > Tell your healthcare professional about **all prescription medicines, OTC medicines, vitamins and herbal supplements** before starting treatment. --- ## Storage Information * Store at **room temperature**, according to the manufacturer's instructions. * Protect from excessive heat and moisture. * Keep away from direct sunlight. * Keep tablets in their original packaging. * Keep the container tightly closed. * Keep out of reach of children. * Do not use after the expiry date. --- ## Prescription Status **Chlorthalidone 6.25 mg + Telmisartan 80 mg is generally a prescription medicine.** Because this combination can affect **blood pressure, kidney function and electrolyte levels**, appropriate medical supervision and periodic monitoring may be required. --- ## Genuine Medicine Assurance When purchasing **Chlorthalidone 6.25 mg + Telmisartan 80 mg**: * Purchase only from a **licensed and reputable pharmacy**. * Verify both active ingredients and their strengths. * Check the manufacturer's name and regulatory information. * Verify the batch/lot number and expiry date. * Ensure the packaging is sealed and undamaged. * Check that the tablets and packaging appear consistent with the manufacturer's information. * Avoid products with altered labels or suspicious packaging. * Do not purchase prescription medicines from unauthorized sellers. * Keep the medicine in its original packaging. * If counterfeit medicine is suspected, contact the manufacturer, licensed pharmacy or relevant medicines regulatory authority. --- # Frequently Asked Questions (FAQ) ### 1. What is Chlorthalidone 6.25 mg + Telmisartan 80 mg used for? It is primarily used to **treat high blood pressure (hypertension)** when combination therapy is appropriate. ### 2. What are the ingredients in this medicine? Each tablet contains **chlorthalidone 6.25 mg** and **telmisartan 80 mg**, unless otherwise stated on the product label. ### 3. How does Telmisartan lower blood pressure? Telmisartan blocks angiotensin II at the **AT1 receptor**, helping blood vessels relax and reducing blood pressure. ### 4. How does Chlorthalidone lower blood pressure? Chlorthalidone increases the excretion of sodium and water by the kidneys, helping reduce fluid volume and blood pressure. ### 5. Can Chlorthalidone + Telmisartan be taken once daily? This combination is commonly administered **once daily**, but the exact schedule should follow the prescription and product labeling. ### 6. Does this medicine cause increased urination? Yes. Chlorthalidone is a diuretic and can increase urine production, particularly after taking a dose. ### 7. Should I take this medicine in the morning or at night? Because chlorthalidone can increase urination, taking it **earlier in the day** may be more convenient for many patients. Follow your prescriber's instructions. ### 8. Can I take Chlorthalidone + Telmisartan with food? It can generally be taken **with or without food**. Take it consistently according to your prescribed schedule. ### 9. Can this medicine lower potassium? Chlorthalidone can lower potassium, while telmisartan can increase potassium. Therefore, the effect on potassium varies, and **blood tests may be needed**. ### 10. Can Chlorthalidone + Telmisartan cause dizziness? Yes. Dizziness can occur, particularly when treatment begins or when you are dehydrated or your blood pressure becomes too low. ### 11. Can I take Ibuprofen with Telmisartan and Chlorthalidone? Regular NSAID use may reduce the antihypertensive effect and increase the risk of kidney problems. Consult your healthcare professional before using NSAIDs regularly. ### 12. Can I take potassium supplements with this medicine? Do not start potassium supplements or potassium-containing salt substitutes without medical advice because telmisartan can increase blood potassium. ### 13. Can this medicine be used during pregnancy? **Telmisartan should not be used during pregnancy** because medicines affecting the renin-angiotensin system can cause serious fetal harm. ### 14. Can this medicine affect kidney function? Yes. Telmisartan can alter kidney function in susceptible patients, and dehydration or certain drug combinations can increase this risk. Kidney function may need monitoring. ### 15. Can Chlorthalidone worsen gout? Yes. Chlorthalidone can increase **uric acid levels** and may trigger or worsen gout in susceptible individuals. ### 16. Can I stop taking this medicine when my blood pressure becomes normal? No. Normal blood pressure usually means the treatment is working. Do not stop the medicine without discussing it with your healthcare professional. ### 17. What should I do if I miss a dose? Take it when remembered unless it is close to the next scheduled dose. **Do not double the dose.** ### 18. Can I drink alcohol while taking this medicine? Alcohol can increase dizziness and low blood pressure. It is best to limit or avoid alcohol according to medical advice. ### 19. How long does Chlorthalidone + Telmisartan take to work? Blood pressure may begin to decrease after treatment starts, but the full response may take **several weeks** and varies between individuals. ### 20. Is Chlorthalidone 6.25 mg + Telmisartan 80 mg available without a prescription? It is generally a **prescription medicine**, although regulatory requirements may vary by country. --- ## Medical Disclaimer This information about **Chlorthalidone 6.25 mg + Telmisartan 80 mg** is provided for educational and general informational purposes only. It is **not a substitute for professional medical advice, diagnosis or treatment**. This medicine can affect **blood pressure, kidney function and electrolyte levels**. Regular monitoring may be necessary, particularly in people with kidney disease, diabetes, heart failure, dehydration or conditions affecting potassium levels. **Telmisartan must not be used during pregnancy.** Seek medical advice promptly if pregnancy occurs while taking this medicine. Always inform your healthcare professional about all medicines and supplements you take, particularly potassium supplements, potassium-sparing diuretics, NSAIDs and lithium. Do not start, stop or change the dose without professional medical guidance.