TELMI 80 AM

# Amlodipine 5 mg + Telmisartan 80 mg ## SHORT DESCRIPTION **Amlodipine 5 mg + Telmisartan 80 mg** is a combination medicine used primarily to manage **high blood pressure (hypertension)**. Amlodipine is a calcium channel blocker that relaxes blood vessels, while telmisartan is an angiotensin II receptor blocker (ARB) that prevents angiotensin II from tightening blood vessels. Together, these medicines help lower blood pressure and may reduce the long-term risk of complications associated with uncontrolled hypertension, such as stroke, heart attack, and kidney damage. ## KEY BENEFITS * Helps lower high blood pressure * Relaxes and widens blood vessels * Provides complementary blood-pressure-lowering effects * Helps maintain blood pressure control throughout the day when taken as prescribed * May reduce the risk of cardiovascular complications associated with uncontrolled hypertension * Convenient combination of two antihypertensive medicines in one tablet ## USES / INDICATIONS Amlodipine 5 mg + Telmisartan 80 mg may be prescribed for: * **Hypertension (high blood pressure)** * Blood pressure that is not adequately controlled with a single medicine * Patients who require combination therapy with a calcium channel blocker and an ARB * Long-term cardiovascular risk reduction through effective blood-pressure control The medicine should be used as part of an overall hypertension-management plan that may include a healthy diet, physical activity, weight management, and other lifestyle measures. ## HOW IT WORKS ### Amlodipine Amlodipine is a **calcium channel blocker (CCB)**. It reduces the entry of calcium into vascular smooth muscle cells, causing the blood vessels to relax and widen. **Amlodipine → Relaxes blood vessels → Reduces vascular resistance → Lowers blood pressure** ### Telmisartan Telmisartan is an **angiotensin II receptor blocker (ARB)**. It blocks the action of angiotensin II at AT1 receptors. This prevents blood vessels from narrowing and reduces aldosterone-related effects that can increase blood pressure. **Telmisartan → Blocks angiotensin II → Prevents vasoconstriction → Lowers blood pressure** ### Combined Action The two medicines work through different mechanisms: **Amlodipine + Telmisartan → Complementary blood-vessel relaxation → Improved blood-pressure control** ## DOSAGE & ADMINISTRATION Take **Amlodipine 5 mg + Telmisartan 80 mg exactly as prescribed** by your doctor. * Take the tablet once daily if prescribed on a once-daily schedule. * Try to take it at the same time each day. * Swallow the tablet with water. * It can generally be taken with or without food. * Do not crush or chew the tablet unless the product instructions specifically allow it. * Continue treatment even if you feel well, unless your doctor tells you to stop. * Monitor your blood pressure regularly as advised. ### Missed Dose Take the missed dose when remembered unless it is nearly time for your next dose. **Do not take two doses together** to compensate for a missed dose. ## SIDE EFFECTS Possible side effects include: * Dizziness * Headache * Tiredness * Swelling of the ankles or feet * Flushing * Palpitations * Nausea * Low blood pressure * Increased potassium levels Amlodipine commonly causes **peripheral edema (ankle or leg swelling)**. Telmisartan may cause dizziness, particularly when treatment is started or the dose is changed. ### Serious Side Effects Seek immediate medical attention if you experience: * Severe dizziness or fainting * Swelling of the face, lips, tongue, or throat * Difficulty breathing or swallowing * Severe allergic reaction * Significant reduction in urine output * Severe weakness or abnormal heartbeat ## PRECAUTIONS & WARNINGS ### Low Blood Pressure This medicine may cause excessive blood-pressure reduction, particularly in people who are dehydrated or taking other blood-pressure-lowering medicines. Rise slowly from sitting or lying positions if you experience dizziness. ### Kidney Disease Telmisartan affects the renin-angiotensin system and may affect kidney function in susceptible patients. Your doctor may monitor kidney function and blood potassium levels. ### High Potassium Telmisartan can increase potassium levels. Tell your doctor if you have kidney disease or take potassium supplements or potassium-containing salt substitutes. ### Liver Disease Tell your doctor if you have liver disease. Telmisartan is primarily eliminated through the liver, and dosing may require particular consideration in patients with hepatic impairment. ### Heart Conditions Tell your doctor if you have heart disease, severe aortic stenosis, or other cardiovascular conditions. ### Pregnancy **Telmisartan should not be used during pregnancy**, particularly after pregnancy is recognized, because medicines that act on the renin-angiotensin system can cause fetal injury or death. Contact your doctor immediately if you become pregnant while taking this medicine. ### Breastfeeding Consult your healthcare professional before using this combination while breastfeeding. ### Dehydration Severe dehydration, vomiting, diarrhea, or excessive sweating can increase the risk of low blood pressure and kidney problems while taking telmisartan. ### Surgery Tell your doctor or anesthetist that you are taking this medicine before undergoing surgery. ## DRUG INTERACTIONS Tell your doctor or pharmacist about all medicines, supplements, and herbal products you take. Important interactions may include: * Other antihypertensive medicines * Potassium supplements * Potassium-containing salt substitutes * Potassium-sparing diuretics * NSAIDs such as ibuprofen, naproxen, and diclofenac * Lithium * ACE inhibitors * Other ARBs * Aliskiren * Certain medicines affecting blood pressure or kidney function * Certain CYP3A4 inhibitors or inducers may affect amlodipine exposure ### NSAIDs Regular use of NSAIDs may reduce the blood-pressure-lowering effect of telmisartan and may increase the risk of kidney impairment in susceptible patients. ### Potassium-Increasing Medicines Combining telmisartan with potassium supplements, potassium-sparing diuretics, or potassium-containing salt substitutes may increase blood potassium levels. ### Lithium Telmisartan may increase lithium concentrations and the risk of lithium toxicity. Close monitoring is generally required if these medicines are used together. ### Other Renin-Angiotensin System Medicines Combining telmisartan with an ACE inhibitor, another ARB, or aliskiren is generally not recommended unless specifically directed and monitored by a specialist. ## STORAGE INFORMATION * Store according to the manufacturer's instructions. * Keep at room temperature unless the product label specifies otherwise. * Protect from excessive heat, moisture, and direct sunlight. * Keep the tablets in their original packaging. * Keep out of reach and sight of children. * Do not use after the expiry date. * Keep the blister or container properly sealed until use. ## PRESCRIPTION STATUS **Amlodipine 5 mg + Telmisartan 80 mg is generally a prescription medicine.** It should be used under medical supervision, particularly because the combination can affect blood pressure, kidney function, and potassium levels. ## GENUINE MEDICINE ASSURANCE To help ensure you receive genuine Amlodipine 5 mg + Telmisartan 80 mg: * Purchase from a licensed and reputable pharmacy. * Check the medicine name and strength. * Verify the manufacturer's information. * Check the batch number and expiry date. * Ensure the packaging is sealed and undamaged. * Avoid products with altered labels or suspicious packaging. * Purchase medicines from authorized sources. * Ask your pharmacist to verify the product if you have concerns about authenticity. ## FAQ SECTION ### What is Amlodipine 5 mg + Telmisartan 80 mg used for? It is primarily used to **treat high blood pressure (hypertension)** when combination therapy is appropriate. ### What does Amlodipine do? Amlodipine relaxes and widens blood vessels, reducing resistance to blood flow and helping lower blood pressure. ### What does Telmisartan do? Telmisartan blocks the action of angiotensin II, a hormone that causes blood vessels to narrow. This helps blood vessels remain relaxed and lowers blood pressure. ### Is Amlodipine + Telmisartan good for high blood pressure? Yes. The combination is specifically used to control hypertension when treatment with one medicine alone may not provide adequate blood-pressure control. ### Can I take Amlodipine + Telmisartan every day? Yes, when prescribed as a regular daily treatment. Take it consistently at the prescribed time and do not discontinue it without consulting your doctor. ### Does Amlodipine + Telmisartan lower blood pressure immediately? It begins lowering blood pressure after a dose, but optimal blood-pressure control develops with regular treatment. The full therapeutic effect may take time. ### Can Amlodipine + Telmisartan cause dizziness? Yes. Dizziness can occur, particularly when starting treatment, increasing the dose, or when blood pressure becomes too low. ### Can Amlodipine + Telmisartan cause ankle swelling? Yes. **Amlodipine can cause swelling of the ankles or feet**, known as peripheral edema. Inform your doctor if swelling is persistent or severe. ### Can I take this medicine with food? Amlodipine and telmisartan can generally be taken with or without food. Follow the specific instructions provided with your product. ### What should I do if I miss a dose? Take it when you remember unless it is nearly time for the next dose. Do not take a double dose. ### Can I stop Amlodipine + Telmisartan when my blood pressure becomes normal? Do not stop treatment on your own. Normal blood pressure may indicate that the medicine is controlling your condition effectively. Your doctor should decide whether treatment needs to be changed. ### Can I take Amlodipine + Telmisartan during pregnancy? **Telmisartan should not be used during pregnancy.** Contact your healthcare professional immediately if you become pregnant while taking this medicine. ### Can I take this medicine while breastfeeding? Consult your doctor before taking this combination while breastfeeding. ### Can I take ibuprofen with Amlodipine + Telmisartan? Regular NSAID use, including ibuprofen, may affect blood-pressure control and kidney function. Ask your healthcare professional before using NSAIDs regularly. ### Can I take potassium supplements with Telmisartan? Do not take potassium supplements or potassium-containing salt substitutes unless your healthcare professional recommends them. Telmisartan can increase blood potassium. ### Does Amlodipine + Telmisartan protect the heart? Effective blood-pressure control can reduce the long-term risk of cardiovascular complications such as stroke and heart disease. The medicine should be taken as part of a comprehensive cardiovascular-risk management plan. ### Is Amlodipine + Telmisartan a diuretic? No. Neither amlodipine nor telmisartan is a traditional diuretic or water pill. ### Does Telmisartan affect the kidneys? Telmisartan can affect kidney function in some patients. It may be beneficial for certain patients with cardiovascular or kidney-related conditions, but kidney function and potassium may need monitoring. ### Can I drink alcohol while taking Amlodipine + Telmisartan? Alcohol may increase dizziness or lower blood pressure further. Discuss alcohol consumption with your healthcare professional. ### Can I drive after taking Amlodipine + Telmisartan? If the medicine causes dizziness, light-headedness, or weakness, avoid driving or operating machinery until you feel well and know how the medicine affects you. ### What happens if I take too much? An overdose may cause excessive low blood pressure, dizziness, fainting, rapid heartbeat, or other serious effects. Seek urgent medical attention if you suspect an overdose. ## MEDICAL DISCLAIMER This information about **Amlodipine 5 mg + Telmisartan 80 mg** is provided for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Use this medicine only as prescribed by a qualified healthcare professional. **Telmisartan can cause serious fetal harm and should not be used during pregnancy.** Blood pressure, kidney function, and potassium levels may require monitoring in appropriate patients. Do not start, stop, or change the dose without medical advice. Seek immediate medical attention for severe dizziness or fainting, difficulty breathing, swelling of the face or throat, or other serious symptoms. Always follow the product label and your doctor's or pharmacist's instructions regarding dosage, interactions, precautions, pregnancy, breastfeeding, and duration of treatment.