TENEPRIDE M-1000

# METFORMIN 1000 MG + TENELIGLIPTIN 20 MG ## SHORT DESCRIPTION **Metformin 1000 mg + Teneligliptin 20 mg** is an oral antidiabetic combination used to help control **blood glucose levels in adults with type 2 diabetes mellitus** when diet and exercise alone, or a single medicine, do not provide adequate glycemic control. Metformin improves insulin sensitivity and reduces glucose production by the liver, while teneligliptin is a **DPP-4 inhibitor** that enhances glucose-dependent insulin release and reduces glucagon secretion. > **Important:** This medicine is intended for type 2 diabetes and is **not a substitute for a healthy diet, physical activity, or regular blood-glucose monitoring**. --- ## KEY BENEFITS * Helps improve **blood glucose control** in adults with type 2 diabetes. * Combines two complementary antidiabetic mechanisms. * Metformin helps reduce excessive glucose production by the liver. * Teneligliptin enhances the body's **glucose-dependent insulin response**. * May help reduce fasting and post-meal blood glucose levels. * Generally has a relatively low risk of hypoglycemia when used without insulin or insulin-releasing medicines. --- ## USES / INDICATIONS Metformin + Teneligliptin may be prescribed for: 1. **Type 2 diabetes mellitus** 2. Inadequate blood-glucose control with metformin alone. 3. Patients requiring combination therapy with metformin and a DPP-4 inhibitor. 4. Improvement of glycemic control alongside diet and exercise. ### Not Intended For * **Type 1 diabetes mellitus** * Diabetic ketoacidosis * Treatment of diabetic coma or severe acute hyperglycemia without medical supervision --- ## HOW IT WORKS ### Metformin 1000 mg Metformin is a **biguanide antidiabetic medicine**. It primarily: * Decreases glucose production by the liver. * Improves insulin sensitivity. * Helps peripheral tissues use glucose more effectively. * Reduces intestinal glucose absorption to a smaller extent. Metformin does **not normally stimulate the pancreas to release insulin**, so when used alone it has a relatively low risk of causing hypoglycemia. ### Teneligliptin 20 mg Teneligliptin is a **DPP-4 (dipeptidyl peptidase-4) inhibitor**. It prevents the rapid breakdown of incretin hormones such as GLP-1 and GIP. This helps: * Increase insulin release when blood glucose is elevated. * Reduce glucagon secretion when glucose is elevated. * Decrease hepatic glucose production. * Improve post-meal and overall glucose control. ### Combined Action **Metformin → reduces hepatic glucose production + improves insulin sensitivity** **Teneligliptin → enhances glucose-dependent insulin activity** Together, they provide complementary glucose-lowering effects. --- ## DOSAGE & ADMINISTRATION ### Usual Adult Considerations The appropriate regimen depends on the patient's: * Current diabetes treatment * HbA1c and blood glucose levels * Kidney function * Liver function * Tolerability * Other medicines A **1000 mg metformin + 20 mg teneligliptin** combination should be taken exactly as prescribed. ### Administration * Take the medicine according to your prescription. * Metformin-containing formulations are generally taken **with meals** to reduce gastrointestinal side effects. * Swallow tablets whole unless the product specifically permits splitting or crushing. * Do not change the dose without medical advice. * Continue recommended diet and exercise. ### Kidney Function Kidney function should be assessed before and during metformin treatment. Metformin may need to be reduced or discontinued in patients with significant renal impairment because of the risk of **metformin-associated lactic acidosis**. ### Missed Dose Take the missed dose when remembered unless it is nearly time for the next scheduled dose. **Do not take two doses at once.** --- ## SIDE EFFECTS ### Common Side Effects Possible side effects include: * Nausea * Diarrhea * Abdominal discomfort * Bloating * Indigestion * Reduced appetite * Headache * Dizziness * Metallic taste Gastrointestinal effects are particularly common when starting metformin or increasing its dose. ### Other Possible Effects Teneligliptin may occasionally cause: * Constipation * Skin rash * Upper respiratory symptoms * Joint pain ### Serious Side Effects Seek medical attention if you experience: * Severe or persistent abdominal symptoms * Severe allergic reaction * Difficulty breathing * Facial, lip, or tongue swelling * Severe skin rash or blistering * Unexplained muscle pain or weakness * Severe weakness, rapid breathing, or unusual sleepiness ### Lactic Acidosis A rare but potentially serious complication associated with metformin is **lactic acidosis**. Symptoms may include: * Extreme weakness * Unusual tiredness * Difficulty breathing * Persistent vomiting * Abdominal discomfort * Dizziness * Feeling unusually cold * Slow or irregular heartbeat Seek urgent medical attention if these symptoms occur. --- ## PRECAUTIONS & WARNINGS ### Kidney Disease Metformin is primarily eliminated through the kidneys. Kidney function should be checked before and during treatment. ### Dehydration Severe vomiting, diarrhea, fever, or dehydration can increase the risk of kidney problems and metformin-associated lactic acidosis. Seek medical advice if significant dehydration occurs. ### Contrast Imaging Metformin may need to be temporarily stopped around certain **iodinated contrast imaging procedures**, depending on kidney function and the type of procedure. Follow the instructions of your healthcare professional. ### Liver Disease Tell your healthcare professional if you have significant liver disease or a history of liver problems. ### Alcohol Excessive alcohol consumption can increase the risk of **lactic acidosis** associated with metformin. Avoid excessive alcohol intake. ### Pancreatitis DPP-4 inhibitors have been associated with reports of acute pancreatitis. Seek medical attention for persistent severe abdominal pain, particularly if it radiates to the back and is accompanied by vomiting. ### Heart Failure Tell your healthcare professional if you have a history of heart failure or significant cardiovascular disease. ### Hypoglycemia Metformin + teneligliptin alone generally has a low risk of hypoglycemia. However, the risk increases when used with: * Insulin * Sulfonylureas * Other glucose-lowering medicines ### Vitamin B12 Long-term metformin therapy may reduce **vitamin B12 levels** in some patients. Periodic monitoring may be considered, particularly in patients with anemia, neuropathy, or other risk factors. --- ## DRUG INTERACTIONS ### Insulin and Sulfonylureas Combining this medicine with insulin or sulfonylureas can increase the risk of **hypoglycemia**. Dose adjustment may be required. ### Alcohol Excessive alcohol intake can increase the risk of metformin-associated lactic acidosis. ### Iodinated Contrast Media Certain contrast imaging procedures can require temporary interruption of metformin because of potential kidney effects. ### Cimetidine and Other Renally Eliminated Medicines Some medicines can affect metformin elimination and may require medical review. ### Corticosteroids Medicines such as prednisolone can increase blood glucose and may reduce diabetes control. ### Diuretics Certain diuretics can affect glucose levels and kidney function. ### ACE Inhibitors and Other Blood-Pressure Medicines Some blood-pressure medicines may alter glucose control or kidney function, requiring monitoring in certain patients. ### Other Antidiabetic Medicines Tell your healthcare professional about all diabetes medicines to avoid excessive glucose lowering or duplicate therapy. Always provide a complete list of your prescription medicines, OTC medicines, supplements, and herbal products. --- ## STORAGE INFORMATION * Store according to the manufacturer's instructions. * Keep at room temperature unless otherwise specified. * Protect from excessive heat, moisture, and direct sunlight. * Keep tablets in their original packaging. * Keep out of reach and sight of children. * Do not use after the expiry date. * Do not use tablets from damaged or improperly sealed packaging. --- ## PRESCRIPTION STATUS **Prescription medicine.** Metformin + Teneligliptin should be used under the supervision of a qualified healthcare professional. Availability and prescription requirements may vary according to local regulations. --- ## GENUINE MEDICINE ASSURANCE When purchasing **Metformin 1000 mg + Teneligliptin 20 mg**, obtain it from a **licensed pharmacy or authorized medicine supplier**. Check the package for: * Correct medicine name * Metformin strength: **1000 mg** * Teneligliptin strength: **20 mg** * Manufacturer details * Batch/lot number * Manufacturing date * Expiry date * Intact seal and packaging * Appropriate regulatory information Avoid products with damaged packaging, altered labels, missing batch numbers, or questionable authenticity. --- # FAQ – METFORMIN 1000 MG + TENELIGLIPTIN 20 MG ### 1. What is Metformin 1000 mg + Teneligliptin 20 mg used for? It is used to improve **blood glucose control in adults with type 2 diabetes mellitus**, along with appropriate diet and exercise. ### 2. Is teneligliptin a DPP-4 inhibitor? Yes. Teneligliptin belongs to the **DPP-4 inhibitor** class of oral antidiabetic medicines. ### 3. How does metformin work? Metformin primarily reduces glucose production by the liver and improves the body's sensitivity to insulin. ### 4. How does teneligliptin work? Teneligliptin increases the activity of incretin hormones, helping the body release insulin in response to elevated blood glucose and reduce inappropriate glucagon secretion. ### 5. Can this medicine cure diabetes? No. It helps control blood glucose but **does not cure type 2 diabetes**. Long-term management may include medication, diet, physical activity, weight management, and regular monitoring. ### 6. Does this medicine cause low blood sugar? The combination alone generally has a relatively low risk of hypoglycemia. However, the risk can increase when it is combined with **insulin or sulfonylureas**. ### 7. Why does metformin cause diarrhea? Metformin commonly affects the gastrointestinal tract, particularly when treatment is started or the dose is increased. Taking it with meals can improve tolerability. ### 8. Can Metformin 1000 mg + Teneligliptin 20 mg be taken with food? Metformin is generally better tolerated when taken **with meals**. Follow the specific instructions supplied with your product. ### 9. Can I drink alcohol while taking this medicine? Avoid excessive alcohol consumption because it may increase the risk of serious complications associated with metformin, including **lactic acidosis**. ### 10. Can this medicine be used in kidney disease? It depends on kidney function. Metformin requires particular caution in patients with reduced kidney function, and it may be contraindicated or require adjustment at certain levels of renal impairment. ### 11. Can this medicine cause vitamin B12 deficiency? Long-term metformin use can reduce vitamin B12 levels in some people. Your healthcare professional may recommend monitoring if you have risk factors or symptoms. ### 12. Can teneligliptin cause pancreatitis? Pancreatitis has been reported with DPP-4 inhibitors. Seek medical attention for **persistent severe abdominal pain**, particularly if accompanied by vomiting. ### 13. Can I take this medicine with insulin? It may be prescribed with insulin in some patients, but the combination can increase the risk of **hypoglycemia**. Doses should be determined by a healthcare professional. ### 14. What happens if I miss a dose? Take the missed dose when remembered unless it is nearly time for the next dose. **Do not double the next dose.** ### 15. Can I stop taking this medicine when my blood sugar improves? Do not stop diabetes medication without medical advice. Blood glucose can rise again when treatment is discontinued. ### 16. Is this medicine suitable for type 1 diabetes? No. This combination is intended for **type 2 diabetes** and is not a replacement for insulin in type 1 diabetes. ### 17. Can this medicine be used during pregnancy? Diabetes treatment during pregnancy requires individualized medical supervision. Consult your healthcare professional before starting, stopping, or changing this medicine during pregnancy. ### 18. Can I take this medicine while breastfeeding? Discuss its use with your healthcare professional, who can assess the benefits and potential risks based on your individual circumstances. ### 19. Does Metformin + Teneligliptin cause weight gain? Metformin is generally considered **weight-neutral or associated with modest weight loss**, while teneligliptin is generally considered weight-neutral. Individual responses can vary. ### 20. Is Metformin 1000 mg + Teneligliptin 20 mg available without a prescription? It is generally a **prescription medicine**, although dispensing regulations vary by country. --- ## MEDICAL DISCLAIMER This information about **Metformin 1000 mg + Teneligliptin 20 mg** is provided for general educational purposes only and does not replace professional medical advice, diagnosis, or treatment. This medicine is intended for the management of **type 2 diabetes mellitus** and should be used together with an appropriate diet, physical activity, and blood-glucose monitoring plan. Metformin can rarely cause **lactic acidosis**, particularly in patients with significant kidney impairment or other risk factors. Teneligliptin and other DPP-4 inhibitors have also been associated with uncommon but potentially serious adverse effects such as pancreatitis and severe hypersensitivity reactions. Always inform your healthcare professional about kidney or liver disease, heart problems, alcohol use, pregnancy, and all medicines you take. Follow the **specific product label and prescribed dosage**, and do not change or discontinue diabetes treatment without professional advice.