TENEPRIDE M-500

# Metformin 500 mg + Teneligliptin 20 mg ## Short Description **Metformin 500 mg + Teneligliptin 20 mg** is an oral antidiabetic combination used to help control **blood glucose levels in adults with type 2 diabetes mellitus**, along with a suitable diet and regular physical activity. * **Metformin** belongs to the biguanide class and primarily reduces glucose production by the liver while improving insulin sensitivity. * **Teneligliptin** is a DPP-4 inhibitor that helps increase insulin release in response to elevated blood glucose and reduce excessive glucagon secretion. The combination provides complementary mechanisms for improving blood sugar control. --- ## Key Benefits * Helps control elevated blood glucose in **type 2 diabetes** * Combines two complementary antidiabetic mechanisms * Metformin reduces glucose production by the liver * Metformin improves insulin sensitivity * Teneligliptin enhances glucose-dependent insulin secretion * Teneligliptin helps reduce inappropriate glucagon release * Generally has a low risk of hypoglycemia when used alone or with metformin * Can help improve fasting and post-meal blood glucose levels * May help improve long-term glycemic control when combined with diet and exercise --- ## Uses / Indications ### Type 2 Diabetes Mellitus Metformin + teneligliptin is used to improve blood glucose control in adults with **type 2 diabetes mellitus** when diet and exercise alone are insufficient. It may be prescribed when: * Metformin alone does not provide adequate glucose control * Teneligliptin is added to existing metformin treatment * Combination therapy is considered appropriate for the patient's diabetes management ### Not for Type 1 Diabetes This combination is **not a replacement for insulin in type 1 diabetes** and is not used to treat diabetic ketoacidosis. --- ## How It Works ### Metformin 500 mg Metformin primarily: * Reduces glucose production by the liver * Improves insulin sensitivity * Increases glucose utilization by tissues * Reduces intestinal glucose absorption to a lesser extent Metformin generally does not stimulate insulin secretion, so it has a low risk of hypoglycemia when used alone. ### Teneligliptin 20 mg Teneligliptin is a **DPP-4 (dipeptidyl peptidase-4) inhibitor**. It increases the activity of naturally occurring incretin hormones, particularly GLP-1 and GIP. This helps: * Increase insulin secretion when blood glucose is elevated * Reduce glucagon secretion * Reduce excessive hepatic glucose production ### Combined Action **Metformin → reduces hepatic glucose production + improves insulin sensitivity** **Teneligliptin → increases glucose-dependent insulin release + reduces glucagon** **Combined effect → improved blood glucose control** --- ## Dosage & Administration > **Important:** Dosage should be individualized according to blood glucose control, kidney function, other medicines, age, and the specific formulation prescribed. ### Usual Adult Administration A common fixed-dose combination contains: **Metformin 500 mg + Teneligliptin 20 mg** The exact frequency should follow the **prescribing information for the specific product** and the instructions of the healthcare professional. Teneligliptin is commonly administered **20 mg once daily**, while metformin dosing may vary depending on the formulation and individual requirements. ### How to Take * Take exactly as prescribed. * Metformin-containing products are generally taken **with meals** to reduce gastrointestinal side effects. * Swallow the tablet with water. * If the product is modified-release, swallow it whole unless the product information specifically permits otherwise. * Maintain a consistent meal and medication schedule. ### Missed Dose Take the missed dose when remembered unless it is close to the next scheduled dose. **Do not take two doses at the same time** to compensate for a missed dose. --- ## Side Effects ### Common Side Effects Possible adverse effects include: * Nausea * Diarrhea * Abdominal discomfort * Bloating * Flatulence * Indigestion * Headache * Dizziness * Reduced appetite Gastrointestinal symptoms are particularly common when beginning metformin treatment. ### Teneligliptin-Related Effects Some patients may experience: * Headache * Nasopharyngitis or cold-like symptoms * Mild gastrointestinal symptoms * Dizziness ### Low Blood Sugar The combination has a relatively low risk of hypoglycemia when used alone, but the risk increases when used with: * Insulin * Sulfonylureas such as glimepiride or gliclazide * Other medicines that lower blood glucose Symptoms of hypoglycemia can include: * Sweating * Shaking * Hunger * Weakness * Dizziness * Confusion * Fast heartbeat ### Rare but Serious Effects Metformin can rarely cause **lactic acidosis**, particularly in patients with significant kidney impairment or other predisposing conditions. Seek urgent medical attention for severe weakness, unusual sleepiness, breathing difficulty, persistent vomiting, severe abdominal symptoms, or feeling unusually cold. --- ## Precautions & Warnings ### Kidney Function Metformin is eliminated primarily through the kidneys. Kidney function should be assessed before treatment and monitored periodically. Metformin is generally contraindicated in patients with **severe renal impairment (eGFR below 30 mL/min/1.73 m²)**. ### Lactic Acidosis Although rare, metformin-associated lactic acidosis can be serious. Risk may increase with: * Severe kidney impairment * Severe dehydration * Severe infection * Conditions causing low oxygen levels * Significant liver dysfunction * Excessive alcohol intake ### Liver Disease Patients with significant liver disease require medical evaluation before using metformin-containing treatment. ### Pancreatitis DPP-4 inhibitors, including teneligliptin, have been associated with reports of acute pancreatitis. Seek medical attention for **persistent severe abdominal pain**, particularly if it radiates to the back and is accompanied by vomiting. ### Heart Failure Patients with a history of heart failure should inform their healthcare professional. Clinical assessment is appropriate when using DPP-4 inhibitor therapy in patients with significant cardiovascular disease. ### Vitamin B12 Long-term metformin treatment may reduce vitamin B12 absorption in some patients. Periodic assessment may be considered, particularly in people with anemia, neuropathy, or other risk factors for B12 deficiency. ### Alcohol Avoid excessive alcohol consumption because it may increase the risk of complications associated with metformin, including lactic acidosis. ### Dehydration Severe vomiting, diarrhea, fever, or inadequate fluid intake can increase the risk of kidney problems while taking metformin. ### Iodinated Contrast Metformin may need to be temporarily withheld around certain **iodinated contrast imaging procedures**, depending on kidney function and the procedure. ### Pregnancy If you are pregnant or planning pregnancy, discuss your diabetes treatment with your healthcare professional. Diabetes management during pregnancy requires individualized treatment. ### Breastfeeding Consult a healthcare professional before using this combination while breastfeeding. --- ## Drug Interactions ### Insulin and Sulfonylureas Combining this medicine with insulin or sulfonylureas may increase the risk of **hypoglycemia**. ### Alcohol Excessive alcohol consumption can increase the risk of metformin-associated lactic acidosis and may affect blood glucose control. ### Cimetidine Cimetidine may increase metformin exposure and may require medical consideration. ### Carbonic Anhydrase Inhibitors Medicines such as **topiramate, acetazolamide, and zonisamide** may increase the risk of metabolic acidosis when combined with metformin. ### Iodinated Contrast Media Some contrast imaging procedures may require temporary interruption of metformin. ### Rifampicin Rifampicin and other medicines that affect drug-metabolizing enzymes or transporters may alter exposure to some antidiabetic medicines. ### Other Antidiabetic Medicines Using multiple glucose-lowering medicines may increase the risk of hypoglycemia or other adverse effects. Always inform your doctor or pharmacist about all **prescription medicines, over-the-counter products, vitamins, supplements, and herbal medicines** you are taking. --- ## Storage Information * Store according to the manufacturer's recommended temperature. * Keep the tablets in their original packaging. * Protect from moisture and excessive heat. * Keep away from direct sunlight. * Keep the container tightly closed. * Keep out of reach and sight of children. * Do not use after the expiry date. * Do not use tablets from damaged or tampered packaging. --- ## Prescription Status **Metformin 500 mg + Teneligliptin 20 mg is generally a prescription medicine.** It should be used under the supervision of a qualified healthcare professional because diabetes treatment requires appropriate dosing, blood glucose monitoring, and assessment of kidney function. --- ## Genuine Medicine Assurance When purchasing **Metformin 500 mg + Teneligliptin 20 mg**: * Purchase from a **licensed pharmacy or authorized medicine supplier**. * Confirm the strength and formulation on the package. * Check the manufacturer's name and product information. * Verify the batch/lot number and expiry date. * Ensure the packaging and seal are intact. * Do not purchase medicines from suspicious or unauthorized sources. * Check that the tablets have not been damaged by heat or moisture. * If the authenticity of the product is uncertain, consult a pharmacist or contact the manufacturer using the information printed on the package. --- # FAQ – Metformin 500 mg + Teneligliptin 20 mg ### 1. What is Metformin 500 mg + Teneligliptin 20 mg used for? It is used to help control **blood glucose in adults with type 2 diabetes mellitus**, along with diet and exercise. ### 2. What type of medicine is Teneligliptin? Teneligliptin is an oral **DPP-4 inhibitor** used to improve blood glucose control in type 2 diabetes. ### 3. How does Metformin work? Metformin mainly reduces glucose production by the liver and improves the body's sensitivity to insulin. ### 4. How does Teneligliptin lower blood sugar? Teneligliptin increases incretin activity, helping the pancreas release insulin when blood glucose is elevated and reducing inappropriate glucagon secretion. ### 5. Can Metformin + Teneligliptin cure diabetes? **No.** It helps control type 2 diabetes but does not cure the underlying condition. Long-term management generally includes healthy eating, physical activity, monitoring, and appropriate medication. ### 6. Can this medicine be used for Type 1 diabetes? No. It is not a substitute for insulin in type 1 diabetes and is not used to treat diabetic ketoacidosis. ### 7. Does Metformin + Teneligliptin cause low blood sugar? The risk is generally low when used alone, but hypoglycemia can occur, particularly when combined with insulin or sulfonylureas. ### 8. What are the common side effects of Metformin? Common side effects include **nausea, diarrhea, abdominal discomfort, bloating, flatulence, and indigestion**. ### 9. Can Metformin cause vitamin B12 deficiency? Yes. Long-term metformin therapy can reduce vitamin B12 absorption in some patients. Your healthcare professional may recommend testing when clinically appropriate. ### 10. Can this medicine cause pancreatitis? DPP-4 inhibitors have been associated with reports of acute pancreatitis. Seek medical attention if you develop persistent, severe abdominal pain, particularly with vomiting. ### 11. Should Metformin be taken with food? Taking metformin with meals generally helps reduce gastrointestinal side effects and may improve tolerability. ### 12. What happens if I miss a dose? Take the dose when remembered unless it is nearly time for the next dose. **Do not double the next dose.** ### 13. Can I drink alcohol while taking Metformin + Teneligliptin? Avoid excessive alcohol because it may increase the risk of complications associated with metformin, including lactic acidosis. ### 14. Can people with kidney disease take this medicine? Kidney function must be assessed because metformin has specific restrictions in renal impairment. Patients with severe kidney impairment generally should not use metformin. ### 15. Can I take this medicine with insulin? It may be prescribed with insulin in some patients, but the combination can increase the risk of hypoglycemia. Medical supervision is required. ### 16. Can I take this medicine with glimepiride? It may be prescribed as part of combination diabetes therapy, but adding glimepiride can increase the risk of hypoglycemia. Only use the combination under medical supervision. ### 17. Can Metformin + Teneligliptin be taken during pregnancy? Pregnancy requires individualized diabetes management. Consult your healthcare professional before starting, stopping, or changing treatment. ### 18. Can I take Metformin + Teneligliptin while breastfeeding? Consult your healthcare professional before use during breastfeeding. ### 19. Does this medicine cause weight gain? Metformin is generally weight-neutral or may be associated with modest weight loss. Teneligliptin is generally considered weight-neutral, although individual responses can vary. ### 20. Can this medicine cause diarrhea? Yes. **Diarrhea is a common side effect of metformin**, especially during the initial period of treatment. ### 21. Can I stop the medicine when my blood sugar becomes normal? Do not stop treatment without medical advice. Normal blood glucose may indicate that the treatment is working effectively. ### 22. How long does Metformin + Teneligliptin take to work? Both medicines begin affecting glucose regulation after administration, but the full treatment response is assessed over time using blood glucose measurements and tests such as **HbA1c**. ### 23. Can I take other diabetes medicines with this combination? Other diabetes medicines may sometimes be used together, but the combination should be prescribed and monitored by a healthcare professional. ### 24. What tests may be needed while taking this medicine? Monitoring may include **blood glucose, HbA1c, kidney function, and vitamin B12 levels when appropriate**. Additional monitoring may be recommended based on your health status. ### 25. Is Metformin 500 mg + Teneligliptin 20 mg available without a prescription? It is generally considered a **prescription medicine**, although availability and legal classification can vary by country. ### 26. Is Metformin 500 mcg the same as Metformin 500 mg? No. **500 mg is 1,000 times greater than 500 mcg.** Metformin tablets are commonly labeled in milligrams. Always verify the strength printed on the medicine package. --- ## Medical Disclaimer This information about **Metformin 500 mg + Teneligliptin 20 mg** is provided for **educational and informational purposes only** and is not a substitute for professional medical advice, diagnosis, or treatment. > **Strength clarification:** Your requested strength was written as **Metformin 500 mcg**. Standard metformin tablet strengths are generally expressed in **mg**, so this content assumes the intended strength is **Metformin 500 mg + Teneligliptin 20 mg**. Verify the actual product label before use or publication. The appropriate treatment and dosage depend on blood glucose control, kidney and liver function, other medicines, age, and individual medical circumstances. Do not start, stop, or change diabetes medication without professional guidance. Seek urgent medical attention for severe hypoglycemia, persistent severe abdominal pain, difficulty breathing, severe weakness, unusual sleepiness, or other serious symptoms. Always follow the manufacturer's product information and the instructions of your doctor or pharmacist.